Evidence map›Paper›PMID 31738970›Full record

ReviewMolecular and cellular endocrinology2020

Pinopodes: Recent advancements, current perspectives, and future directions.

Kelsey E Quinn, Brooke C Matson, Margeaux Wetendorf, Kathleen M Caron

Open access · greenAbstract readReview
In one paragraph

Review in Molecular and cellular endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
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  5. PGEAnimals : an open access journal from MDPI · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kelsey E QuinnDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, 27599, USA.
Brooke C MatsonDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, 27599, USA.
Margeaux WetendorfDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, 27599, USA.
Kathleen M CaronDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, 27599, USA. Electronic address: kathleen_caron@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Adrenomedullin Signaling at the Maternal-Fetal InterfaceR01HD060860 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kathleen M Caron · 2009 to 2026
$4.8M
Compartmental Adrenomedullin Signaling in the Uterus during ImplantationF30HD085652 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MATSON, BROOKE · 2016 to 2019
$140k
NCI NIH HHS P30 CA016086NICHD NIH HHS F30 HD085652NICHD NIH HHS R01 HD060860
6 · The paper itself

Abstract

Successful embryo implantation is a complex and highly regulated process involving precise synchronization between the fetal-derived trophoblast cells and maternal uterine luminal epithelium. Multiple endocrine-driven factors are important for controlling the timely receptivity of the uterus, and this complexity underscores implantation failure as a major cause of recurrent infertility associated with assisted reproductive technologies. One particular cellular structure often hypothesized to promote receptivity is the pinopode or uterodome - a hormonally regulated, large cellular protrusion on the uterine epithelial surface. Recent clinical studies associate pinopodes with favorable fertility outcomes in women, and because they are directly linked to an increase in progesterone levels, the potential utility of these hormone-regulated cell biological structures in predicting or improving implantation in a clinical setting holds promise. In this review, we aim to generate interest in pinopodes from the broader cell biology and endocrinology communities, re-examine methodologies in pinopode research, and identify priorities for future investigation of pinopode structure and function in women's reproductive health.

Indexed as

AnimalsEndometriumEpitheliumFemaleFertilityHormonesHumansTrophoblastsUterusHormonesEndometrial receptivityImplantationPinopodesProgesteroneUterodomes

Identifiers

PMID31738970
PMCPMC6962535
OpenAlexW2984136994

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.