Evidence map›Paper›PMID 31738927›Full record

Trial reportChest2020

Acute Ventilatory Support During Whole-Body Hybrid Rowing in Patients With High-Level Spinal Cord Injury: A Randomized Controlled Crossover Trial.

Isabelle Vivodtzev, Glen Picard, Felipe X Cepeda, J Andrew Taylor

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Chest, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02865343 nacompletednot on this map

Ventilatory Support to Improve Exercise Training in High Level Spinal Cord Injury

TypeinterventionalSponsorSpaulding Rehabilitation HospitalRan2017 to 2019Enrolled11ConditionsSpinal Cord InjuryArmsNon-invasive Ventilation(NIV), Sham Non-invasive ventilation(NIV)
NCT03267212 nacompletednot on this map

Acute Effect of Ventilatory Support During Exercise in Spinal Cord Injury

TypeinterventionalSponsorSpaulding Rehabilitation HospitalRan2017 to 2019Enrolled15ConditionsSpinal Cord InjuryArmsNon-invasive ventilation(NIV), Sham Non-invasive ventilation(NIV), Functional Electrical Stimulation Row Training (FESRT)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Isabelle VivodtzevDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Boston MA; Cardiovascular Research Laboratory, Spaulding Rehabilitation Hospital, Cambridge, MA. Electronic address: ivivodtzev@partners.org.
Glen PicardCardiovascular Research Laboratory, Spaulding Rehabilitation Hospital, Cambridge, MA.
Felipe X CepedaUniversidade Nove de Julho, São Paulo, SP, Brazil.
J Andrew TaylorDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Boston MA; Cardiovascular Research Laboratory, Spaulding Rehabilitation Hospital, Cambridge, MA.
Harvard University · USSpaulding Rehabilitation Hospital · USUniversidade Nove de Julho · BR

Funding

Hybrid-FES Exercise To Prevent Cardiovascular Declines In Acute Spinal Cord InjuryR01HL117037 · NHLBI · SPAULDING REHABILITATION HOSPITAL · PI TAYLOR, J ANDREW · 2013 to 2024
$4.9M
Ventilatory Support to Improve Exercise Training in High Level Spinal Cord InjuryR21HD088891 · NICHD · SPAULDING REHABILITATION HOSPITAL · PI TAYLOR, J ANDREW · 2016 to 2017
$495k
NHLBI NIH HHS R01 HL117037NICHD NIH HHS R21 HD088891
6 · The paper itself

Abstract

backgroundHigh-level spinal cord injury (SCI) results in profound spinal and supraspinal deficits, leading to substantial ventilatory limitations during whole-body hybrid functional electrical stimulation (FES)-rowing, a form of exercise that markedly increases the active muscle mass via electrically induced leg contractions. This study tested the effect of noninvasive ventilation (NIV) on ventilatory and aerobic capacities in SCI.

methodsThis blinded, randomized crossover study enrolled 19 patients with SCI (level of injury ranging from C4 to T8). All patients were familiar with FES-rowing and had plateaued in their training-related increases in aerobic capacity. Patients performed two FES-rowing peak exercise tests with NIV or without NIV (sham).

resultsNIV increased exercise tidal volume (peak, 1.50 ± 0.31 L vs 1.36 ± 0.34 L; P < .05) and reduced breathing frequency (peak, 35 ± 7 beats/min vs 38 ± 6 beats/min; P < .05) compared with the sham test, leading to no change in alveolar ventilation but a trend toward increased oxygen uptake efficiency (P = .06). In those who reached peak oxygen consumption (Vo

conclusionsAcute NIV can successfully improve ventilatory efficiency during FES exercise in SCI but may not improve Vo TRIAL REGISTRY: ClinicalTrials.gov; Nos.: NCT02865343 and NCT03267212; URL: www.clinicaltrials.gov.

Indexed as

Noninvasive VentilationWater SportsAdultCross-Over StudiesDouble-Blind MethodElectric Stimulation TherapyExercise TestFemaleHumansLegMaleMiddle AgedOxygen ConsumptionSpinal Cord Injuriesexercise testingnoninvasive ventilationpulmonary rehabilitationrespiratory patternspinal cord injury

Identifiers

PMID31738927
PMCPMC7242636
OpenAlexW2986304102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.