Evidence map›Paper›PMID 31738898›Full record

ArticleBiochimica et biophysica acta. Biomembranes2020

Influence of interfacial tryptophan residues on an arginine-flanked transmembrane helix.

Sara J Sustich, Fahmida Afrose, Denise V Greathouse, Roger E Koeppe

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Biomembranes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sara J SustichDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, United States of America.
Fahmida AfroseDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, United States of America.
Denise V GreathouseDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, United States of America.
Roger E KoeppeDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, United States of America. Electronic address: rk2@uark.edu.
University of Arkansas at Fayetteville · US

Funding

Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett, JERRY WARE · 2012 to 2026
$60.9M
NIGMS NIH HHS P20 GM103429
6 · The paper itself

Abstract

The transmembrane helices of membrane proteins often are flanked by interfacial charged or aromatic residues that potentially help to anchor the membrane-spanning protein. For isolated single-span helices, the interfacial residues may be especially important for stabilizing particular tilted transmembrane orientations. The peptide RWALP23 (acetyl-GR

Indexed as

Amino Acid MotifsArginineCell MembraneMembrane ProteinsMolecular Dynamics SimulationProtein Conformation, alpha-HelicalProtein StabilityTryptophanArginineMembrane ProteinsTryptophanArginineDeuterium NMRGALATransmembrane helix unwindingTryptophan

Identifiers

PMID31738898
PMCPMC6943188
OpenAlexW2982760064

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.