ArticlePloS one2019
Flat electrode contacts for vagus nerve stimulation.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Computational modeling of human vagus nerve stimulation with three-dimensional fascicular morphology.APL bioengineering · 2026Article
- The human vagal complex: from gross anatomy to single neurons, from brainstem to abdomen.Research square · 2025Article
- Clinical experience implanting a miniature externally powered vagus nerve stimulator.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Advice for translational neuroscience: move deliberately and build things.Bioelectronic medicine · 2025Article
- Computational modeling of autonomic nerve stimulation: Vagus et al.Current opinion in biomedical engineering · 2024Article
- Multi-Channel Microscale Nerve Cuffs for Spatially Selective Neuromodulation.Micromachines · 2024Article
- Towards enhanced functionality of vagus neuroprostheses through in silico optimized stimulation.Nature communications · 2024Article
- Nonlinear Closed-Loop Predictive Control of Heart Rate and Blood Pressure Using Vagus Nerve Stimulation: An In Silico Study.IEEE transactions on bio-medical engineering · 2023Article
- Deep-learning segmentation of fascicles from microCT of the human vagus nerve.Frontiers in neuroscience · 2023Article
- Fascicles split or merge every ∼560 microns within the human cervical vagus nerve.Journal of neural engineering · 2022Article
- Strategies for precision vagus neuromodulation.Bioelectronic medicine · 2022Review
- Short-pulsed micro-magnetic stimulation of the vagus nerve.Frontiers in physiology · 2022Article
- ASCENT (Automated Simulations to Characterize Electrical Nerve Thresholds): A pipeline for sample-specific computational modeling of electrical stimulation of peripheral nerves.PLoS computational biology · 2021Article
- Assessment of the Use of Multi-Channel Organic Electrodes to Record ENG on Small Nerves: Application to Phrenic Nerve Burst Detection.Sensors (Basel, Switzerland) · 2021Article
- Validation of a parameterized, open-source model of nerve stimulation.Journal of neural engineering · 2021Review
- High intensity VNS disrupts VNS-mediated plasticity in motor cortex.Brain research · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The majority of available systems for vagus nerve stimulation use helical stimulation electrodes, which cover the majority of the circumference of the nerve and produce largely uniform current density within the nerve. Flat stimulation electrodes that contact only one side of the nerve may provide advantages, including ease of fabrication. However, it is possible that the flat configuration will yield inefficient fiber recruitment due to a less uniform current distribution within the nerve. Here we tested the hypothesis that flat electrodes will require higher current amplitude to activate all large-diameter fibers throughout the whole cross-section of a nerve than circumferential designs. Computational modeling and in vivo experiments were performed to evaluate fiber recruitment in different nerves and different species using a variety of electrode designs. Initial results demonstrated similar fiber recruitment in the rat vagus and sciatic nerves with a standard circumferential cuff electrode and a cuff electrode modified to approximate a flat configuration. Follow up experiments comparing true flat electrodes to circumferential electrodes on the rabbit sciatic nerve confirmed that fiber recruitment was equivalent between the two designs. These findings demonstrate that flat electrodes represent a viable design for nerve stimulation that may provide advantages over the current circumferential designs for applications in which the goal is uniform activation of all fascicles within the nerve.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.