Evidence map›Paper›PMID 31738411›Full record

ArticleCardiovascular research2020

Delineating the molecular and histological events that govern right ventricular recovery using a novel mouse model of pulmonary artery de-banding.

Mario Boehm, Xuefei Tian, Yuqiang Mao, Kenzo Ichimura, Melanie J Dufva, Khadem Ali, Svenja Dannewitz Prosseda, Yiwei Shi, Kazuya Kuramoto, Sushma Reddy and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Right ventricle remodelling: fromJournal of molecular and cellular cardiology plus · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. [Respiratory research · 2023
    Article
  10. Article
  11. More than just a small left ventricle: the right ventricular fibroblast and ECM in health and disease.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  12. Review
  13. Mitochondrial Integrity Is Critical in Right Heart Failure Development.International journal of molecular sciences · 2023
    Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Mario BoehmDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, 300 Pasteur Drive, Grand Bld Rm S126B, Stanford, CA 94305, USA.
Xuefei TianDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, 300 Pasteur Drive, Grand Bld Rm S126B, Stanford, CA 94305, USA.
Yuqiang MaoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, 300 Pasteur Drive, Grand Bld Rm S126B, Stanford, CA 94305, USA.
Kenzo IchimuraDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, 300 Pasteur Drive, Grand Bld Rm S126B, Stanford, CA 94305, USA.
Melanie J DufvaDepartment of Bioengineering, University of Colorado Denver, Denver, CO, USA.
Khadem AliDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, 300 Pasteur Drive, Grand Bld Rm S126B, Stanford, CA 94305, USA.
Svenja Dannewitz ProssedaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, 300 Pasteur Drive, Grand Bld Rm S126B, Stanford, CA 94305, USA.
Yiwei ShiDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, 300 Pasteur Drive, Grand Bld Rm S126B, Stanford, CA 94305, USA.
Kazuya KuramotoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, 300 Pasteur Drive, Grand Bld Rm S126B, Stanford, CA 94305, USA.
Sushma ReddyDivision of Cardiology, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Vitaly O KheyfetsDepartment of Bioengineering, University of Colorado Denver, Denver, CO, USA.
Ross J MetzgerVera Moulton Wall Center for Pulmonary Vascular Disease, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
Edda SpiekerkoetterDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Stanford University, 300 Pasteur Drive, Grand Bld Rm S126B, Stanford, CA 94305, USA.
Stanford University · USCardiovascular Institute of the South · USChildren's Hospital Colorado · USChina Medical University · CNJustus-Liebig-Universität Gießen · DE

Funding

Targeting Novel BMPR2 modifiers in Pulmonary Hypertension with Repurposed DrugsR01HL128734 · NHLBI · STANFORD UNIVERSITY · PI SPIEKERKOETTER, EDDA FRAUKE · 2016 to 2020
$2.1M
Non-cardiomyocyte miR-34a Mediates Susceptibility to Right Heart FailureK08HL127277 · NHLBI · STANFORD UNIVERSITY · PI REDDY, SUSHMA · 2015 to 2019
$804k
Inter-ventricular decoupling is an overlooked contributor to right ventricular myocardial stress and dysfunction in pediatric pulmonary hypertensionK25HL133481 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KHEYFETS, VITALY · 2017 to 2021
$605k
NHLBI NIH HHS K08 HL127277NHLBI NIH HHS K25 HL133481NHLBI NIH HHS R01 HL128734
6 · The paper itself

Abstract

aimsThe temporal sequence of events underlying functional right ventricular (RV) recovery after improvement of pulmonary hypertension-associated pressure overload is unknown. We sought to establish a novel mouse model of gradual RV recovery from pressure overload and use it to delineate RV reverse-remodelling events. METHODS AND

resultsSurgical pulmonary artery banding (PAB) around a 26-G needle induced RV dysfunction with increased RV pressures, reduced exercise capacity and caused liver congestion, hypertrophic, fibrotic, and vascular myocardial remodelling within 5 weeks of chronic RV pressure overload in mice. Gradual reduction of the afterload burden through PA band absorption (de-PAB)-after RV dysfunction and structural remodelling were established-initiated recovery of RV function (cardiac output and exercise capacity) along with rapid normalization in RV hypertrophy (RV/left ventricular + S and cardiomyocyte area) and RV pressures (right ventricular systolic pressure). RV fibrotic (collagen, elastic fibres, and vimentin+ fibroblasts) and vascular (capillary density) remodelling were equally reversible; however, reversal occurred at a later timepoint after de-PAB, when RV function was already completely restored. Microarray gene expression (ClariomS, Thermo Fisher Scientific, Waltham, MA, USA) along with gene ontology analyses in RV tissues revealed growth factors, immune modulators, and apoptosis mediators as major cellular components underlying functional RV recovery.

conclusionWe established a novel gradual de-PAB mouse model and used it to demonstrate that established pulmonary hypertension-associated RV dysfunction is fully reversible. Mechanistically, we link functional RV improvement to hypertrophic normalization that precedes fibrotic and vascular reverse-remodelling events.

Indexed as

Ventricular Function, RightVentricular RemodelingAnimalsArterial PressureDisease Models, AnimalExercise ToleranceFibroblastsFibrosisHypertrophy, Right VentricularMaleMice, Inbred C57BLMyocardiumPulmonary Arterial HypertensionPulmonary ArteryRecovery of FunctionSuture TechniquesFibrosisPulmonary hypertensionRecoveryRight ventricle

Identifiers

PMID31738411
PMCPMC7643543
OpenAlexW2986627694

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.