Evidence map›Paper›PMID 31738314›Full record

Observational studyThe journal of trauma and acute care surgery2020

A comparison between the TEG 6s and TEG 5000 analyzers to assess coagulation in trauma patients.

Matthew D Neal, Ernest E Moore, Mark Walsh, Scott Thomas, Rachael A Callcut, Lucy Z Kornblith, Martin Schreiber, Akpofure Peter Ekeh, Adam J Singer, Lawrence Lottenberg and 9 more

Abstract readComparative StudyMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The journal of trauma and acute care surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Initial TEG 6s parameters for risk stratification of hemorrhage-related outcomes in massively transfused trauma patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. The impact of the patient's plasma volume on the amount of fresh frozen plasma needed to normalize the thromboelastographic reaction time.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Viscoelastic testing: an illustrated review of technology and clinical applications.Research and practice in thrombosis and haemostasis · 2023
    Review
  15. Article
  16. Comparison of assessment of coagulation in healthy dogs by the TEG 6s and TEG 5000 viscoelastic analyzers.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Matthew D NealFrom the Departments of Surgery, Critical Care Medicine, and the Clinical and Translational Science Institute (CTSI) (M.D.N.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; Ernest E Moore Shock Trauma Center at Denver Health (E.E.M.), Denver, Colorado; Memorial Hospital of South Bend (M.W., S.T.), South Bend, Indiana; Department of Surgery (R.A.C., L.Z.K.), Zuckerberg San Francisco General Hospital, University of California San Francisco (UCSF), San Francisco, California; Division of Trauma, Critical Care & Acute Care Surgery, Department of Surgery (M.S.), Oregon Health & Science University, Portland, Oregon; Wright State University (A.P.E.), Dayton, Ohio; Stony Brook Department of Emergency Medicine (A.J.S.), Stony Brook University, Stony Brook, New York; Department of Surgery, Florida Atlantic University, St. Mary's Medical Center (L.L.), West Palm Beach, Florida; Division of Trauma, Acute Care, and Critical Care Surgery (M.F.), Baylor University Medical Center, Dallas, Texas; Division of Acute Care Surgery, Department of Surgery (S.E.), Carolinas Medical Center, Charlotte, North Carolina; University of Kansas Medical Center (R.D.W.), University of Kansas, Kansas City, Kansas; Department of Surgery (M.D.G.), University of Cincinnati, Cincinnati, Ohio; SSM Health (C.F.), Saint Louis University Hospital, St Louis, Missouri; Division of Trauma and Acute Care Surgery (D.M.), Medical College of Wisconsin, Milwaukee, Wisconsin; Department of Surgery (N.S.), Massachusetts General Hospital, Boston; and Haemonetics Corporation (J.H., H.E.A.), Braintree, Massachusetts.
Ernest E Moore
Mark Walsh
Scott Thomas
Rachael A Callcut
Lucy Z Kornblith
Martin Schreiber
Akpofure Peter Ekeh
Adam J Singer
Lawrence Lottenberg
Michael Foreman
Susan Evans
Robert D Winfield
Michael D Goodman
Carl Freeman
David Milia
Noelle Saillant
Jan Hartmann
Hardean E Achneck

Funding

Mechanistic Elucidation and Targeted Therapy of Platelet Dysfunction After TraumaR35GM119526 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEAL, MATTHEW D · 2016 to 2025
$3.9M
NIGMS NIH HHS R35 GM119526
6 · The paper itself

Abstract

backgroundTrauma-induced coagulopathy is a major driver of mortality following severe injury. Viscoelastic goal-directed resuscitation can reduce mortality after injury. The TEG 5000 system is widely used for viscoelastic testing. However, the TEG 6s system incorporates newer technology, with encouraging results in cardiovascular interventions. The purpose of this study was to validate the TEG 6s system for use in trauma patients.

methodsMulticenter noninvasive observational study for method comparison conducted at 12 US Levels I and II trauma centers. Agreement between the TEG 6s and TEG 5000 systems was examined using citrated kaolin reaction time (CK.R), citrated functional fibrinogen maximum amplitude (CFF.MA), citrated kaolin percent clot lysis at 30 minutes (CK.LY30), citrated RapidTEG maximum amplitude (CRT.MA), and citrated kaolin maximum amplitude (CK.MA) parameters in adults meeting full or limited trauma team criteria. Blood was drawn ≤1 hour after admission. Assays were repeated in duplicate. Reliability (TEG 5000 vs. TEG 6s analyzers) and repeatability (interdevice comparison) was quantified. Linear regression was used to define the relationship between TEG 6s and TEG 5000 devices.

resultsA total of 475 patients were enrolled. The cohort was predominantly male (68.6%) with a median age of 49 years. Regression line slope estimates (ß) and linear correlation estimates (p) were as follows: CK.R (ß = 1.05, ρ = 0.9), CFF.MA (ß = 0.99, ρ = 0.95), CK.LY30 (ß = 1.01, ρ = 0.91), CRT.MA (TEG 6s) versus CK.MA (TEG 5000) (ß = 1.06, ρ = 0.86) as well as versus CRT.MA (TEG 5000) (ß = 0.93, ρ = 0.93), indicating strong reliability between the devices. Overall, within-device repeatability was better for TEG 6s versus TEG 5000, particularly for CFF.MA and CK.LY30.

conclusionThe TEG 6s device appears to be highly reliable for use in trauma patients, with close correlation to the TEG 5000 device and equivalent/improved within-device reliability. Given the potential advantages of using the TEG 6s device at the site of care, confirmation of agreement between the devices represents an important advance in diagnostic testing. LEVEL OF EVIDENCE: Diagnostic test, level II.

Indexed as

Point-of-Care SystemsAdolescentAdultAgedAged, 80 and overBlood Coagulation DisordersFemaleHumansMaleMiddle AgedThrombelastographyWounds and InjuriesYoung Adult

Identifiers

PMID31738314
PMCPMC7004476

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.