Evidence map›Paper›PMID 31738172›Full record

ArticleJMIR mental health2019

Wearable Technology for High-Frequency Cognitive and Mood Assessment in Major Depressive Disorder: Longitudinal Observational Study.

Francesca Cormack, Maggie McCue, Nick Taptiklis, Caroline Skirrow, Emilie Glazer, Elli Panagopoulos, Tempest A van Schaik, Ben Fehnert, James King, Jennifer H Barnett

Open access · goldAbstract read
In one paragraph

Article in JMIR mental health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
8.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Francesca CormackCambridge Cognition, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0002-4413-177X
Maggie McCueTakeda Pharmaceuticals USA, Deerfield, IL, United States.ORCID https://orcid.org/0000-0003-1953-1795
Nick TaptiklisCambridge Cognition, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0003-0194-9413
Caroline SkirrowCambridge Cognition, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0001-8692-7787
Emilie GlazerCognition Kit, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0003-2769-0139
Elli PanagopoulosCognition Kit, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0001-5744-4815
Tempest A van SchaikCognition Kit, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0001-7745-2249
Ben FehnertCognition Kit, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0002-5371-2154
James KingCognition Kit, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0001-9969-9541
Jennifer H BarnettCambridge Cognition, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0002-4851-5949
Cambridge Cognition (United Kingdom) · GBDeerfield (United States) · USUniversity of Bristol · GBUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCognitive symptoms are common in major depressive disorder and may help to identify patients who need treatment or who are not experiencing adequate treatment response. Digital tools providing real-time data assessing cognitive function could help support patient treatment and remediation of cognitive and mood symptoms.

objectiveThe aim of this study was to examine feasibility and validity of a wearable high-frequency cognitive and mood assessment app over 6 weeks, corresponding to when antidepressant pharmacotherapy begins to show efficacy.

methodsA total of 30 patients (aged 19-63 years; 19 women) with mild-to-moderate depression participated in the study. The new Cognition Kit app was delivered via the Apple Watch, providing a high-resolution touch screen display for task presentation and logging responses. Cognition was assessed by the n-back task up to 3 times daily and depressed mood by 3 short questions once daily. Adherence was defined as participants completing at least 1 assessment daily. Selected tests sensitive to depression from the Cambridge Neuropsychological Test Automated Battery and validated questionnaires of depression symptom severity were administered on 3 occasions (weeks 1, 3, and 6). Exploratory analyses examined the relationship between mood and cognitive measures acquired in low- and high-frequency assessment.

resultsAdherence was excellent for mood and cognitive assessments (95% and 96%, respectively), did not deteriorate over time, and was not influenced by depression symptom severity or cognitive function at study onset. Analyses examining the relationship between high-frequency cognitive and mood assessment and validated measures showed good correspondence. Daily mood assessments correlated moderately with validated depression questionnaires (r=0.45-0.69 for total daily mood score), and daily cognitive assessments correlated moderately with validated cognitive tests sensitive to depression (r=0.37-0.50 for mean n-back).

conclusionsThis study supports the feasibility and validity of high-frequency assessment of cognition and mood using wearable devices over an extended period in patients with major depressive disorder.

Indexed as

cognitiondepressiondigital biomarkersdigital phenotypingecological momentary assessmentmHealthmobile appsmobile healthmood

Identifiers

PMID31738172
PMCPMC6887827
OpenAlexW2965472879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.