ReviewRecent patents on inflammation & allergy drug discovery2020
Onychomycosis: An Updated Review.
Review in Recent patents on inflammation & allergy drug discovery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06971341 (Retrospective Observational Study in Patients With Onychomycosis Treated With Mycoclear® and Ciclopirox), which is not on this map. Cited by 76 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Retrospective Observational Study in Patients With Onychomycosis Treated With Mycoclear® and Ciclopirox
Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it, 164 citations in OpenAlex.
- Meta-analysis of the antifungal activities of three essential oils as alternative therapies in dermatophytosis infections.Journal of applied microbiology · 2022Pooled it
- Trial
- Assessing the Therapeutic Efficacy of Photodynamic Therapy, Fractional COJournal of cosmetic dermatology · 2025Trial
- Combined fractional CO2 laser with topical tioconazole versus Q-switched Nd-YAG laser in the treatment of onychomycosis; a randomized comparative trial.Lasers in medical science · 2024Trial
- Antifungal pulse therapy for onychomycosis: a narrative review.European journal of clinical pharmacology · 2026Review
- First case report of onychomycosis caused byMedical mycology case reports · 2026Article
- Onychomycosis caused byMedical mycology case reports · 2026Article
- Antibiofilm efficacy of 1,064-nm neodymium-doped yttrium aluminum garnet laser onMicrobiology spectrum · 2026Article
- Review
- Molecular analysis of squalene epoxidase gene mutations in Trichophyton rubrum from clinical onychomycosis samples in South Korea.Scientific reports · 2026Article
- Huangqin decoction disrupts energy metabolism of Trichophyton rubrum, with isocitrate lyase as a potential target.Scientific reports · 2026Article
- Diagnostic accuracy of fluorescence microscopy of hematoxylin-eosin-stained nail sections for onychomycosis.Frontiers in medicine · 2026Article
- An Uncommon Clinical Patterns of Proximal Subungual Onychomycosis Caused byClinical, cosmetic and investigational dermatology · 2026Article
- Formulation and development of thymoquinone-loaded ufasome hydrogel for effective treatment of onychomycosis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Epidemiology and fungal species distribution of onychomycosis and other superficial mycoses in the coastal city of Ningbo, China.Frontiers in fungal biology · 2026Article
- Onychomycosis prevalence etiology and associated factors in women using nail cosmetics attending Mbarara regional referral hospital dermatology clinic Uganda.Scientific reports · 2025Article
- Nationwide epidemiology of candidiasis in Panama, 2010-2020.Scientific reports · 2025Article
- Treating Onychomycosis with Efinaconazole: Considerations for Diverse Patient Groups.Journal of fungi (Basel, Switzerland) · 2025Review
- Shifting etiological agents of dermatophytosis: a molecular epidemiological study from Iran.Iranian journal of microbiology · 2025Article
- Overexpression of efflux pump and biofilm associated genes in itraconazole resistant Candida albicans isolates causing onychomycosis.Scientific reports · 2025Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOnychomycosis is a common fungal infection of the nail.
objectiveThe study aimed to provide an update on the evaluation, diagnosis, and treatment of onychomycosis.
methodsA PubMed search was completed in Clinical Queries using the key term "onychomycosis". The search was conducted in May 2019. The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews published within the past 20 years. The search was restricted to English literature. Patents were searched using the key term "onychomycosis" in www.freepatentsonline.com.
resultsOnychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. The diagnosis can be confirmed by direct microscopic examination with a potassium hydroxide wet-mount preparation, histopathologic examination of the trimmed affected nail plate with a periodic-acid-Schiff stain, fungal culture, or polymerase chain reaction assays. Laboratory confirmation of onychomycosis before beginning a treatment regimen should be considered. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis and is a therapeutic option when oral antifungal agents are contraindicated or cannot be tolerated. Recent patents related to the management of onychomycosis are also discussed.
conclusionOral antifungal therapies are effective, but significant adverse effects limit their use. Although topical antifungal therapies have minimal adverse events, they are less effective than oral antifungal therapies, due to poor nail penetration. Therefore, there is a need for exploring more effective and/or alternative treatment modalities for the treatment of onychomycosis which are safer and more effective.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.