ArticleMacromolecular rapid communications2019
Purifying Low-Volume Combinatorial Polymer Libraries with Gel Filtration Columns.
Article in Macromolecular rapid communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Mapping Biomaterial Complexity by Machine Learning.Tissue engineering. Part A · 2024Review
- Navigating the Expansive Landscapes of Soft Materials: A User Guide for High-Throughput Workflows.ACS polymers Au · 2023Review
- From monomer to micelle: a facile approach to the multi-step synthesis of block copolymersChemical science · 2023Article
- Machine-Learning-Guided Discovery ofJournal of the American Chemical Society · 2021Article
- Automation and data-driven design of polymer therapeutics.Advanced drug delivery reviews · 2021Review
- Automated PET-RAFT Polymerization Towards Pharmaceutical Amorphous Solid Dispersion Development.ACS applied polymer materials · 2021Article
- Automated Polymer Purification Using Dialysis.Polymers · 2020Article
- Automation of Controlled/Living Radical Polymerization.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Recent advances in oxygen-tolerant controlled/living radical polymer chemistry now enable efficient synthesis of diverse and combinatorial polymer libraries. While library synthesis has been dramatically simplified, equally efficient purification strategies for removal of small-molecule impurities are not yet established in high throughput settings. It is shown that gel filtration columns for chromatography frequently used in the protein science community are well suited for high throughput polymer purification. Using either single-use columns or gel filtration plates, the purification of 32 diverse polymers is demonstrated in a library with >95% removal of small molecule impurities and >85% polymer retention in a single purification step. Doing so replaces the typical procedure of polymer precipitation, which requires solvent optimization for each polymer in a complex library. Overall, this work raises awareness in the polymer science community that gel filtration is amenable to purification of large polymer libraries and can speed up the progress of combinatorial polymer chemistry.
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Registered trials
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