ArticleJournal of the Endocrine Society2019
Testosterone Treatment in Infants With 47,XXY: Effects on Body Composition.
Article in Journal of the Endocrine Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Growing up with Klinefelter syndrome: challenges of care in children and adolescents and patients advocacy.Endocrine · 2026Review
- Article
- Sex chromosome aneuploidies and fertility: 47,XXY, 47,XYY, 47,XXX and 45,X/47,XXX.Endocrine connections · 2023Review
- Article
- Reproductive hormones, bone mineral content, body composition, and testosterone therapy in boys and adolescents with Klinefelter syndrome.Endocrine connections · 2023Article
- Biochemical identification of prepubertal boys with Klinefelter syndrome by combined reproductive hormone profiling using machine learning.Endocrine connections · 2023Article
- Review
- Integrative epigenome profiling of 47XXY provides insights into whole genomic DNA hypermethylation and active chromatin accessibility.Frontiers in molecular biosciences · 2023Article
- An optimal growth pattern during pregnancy and early childhood associates with better fertility in men.European journal of endocrinology · 2022Article
- Metabolic and Nutritional Aspects in Paediatric Patients with Klinefelter Syndrome: A Narrative Review.Nutrients · 2022Review
- Population-based Assessment of Cardiometabolic-related Diagnoses in Youth With Klinefelter Syndrome: A PEDSnet Study.The Journal of clinical endocrinology and metabolism · 2022Article
- Adverse pathophysiological influence of early testosterone therapy on the testes of boys with higher grade sex chromosome aneuploidies (HGAs): a retrospective, cross-sectional study.Journal of endocrinological investigation · 2021Article
- At what age should we attempt to retrieve sperm from males with Klinefelter syndrome.Translational andrology and urology · 2021Review
- Case Report: Infant With Congenital Adrenal Hyperplasia and 47,XXY.Frontiers in genetics · 2021Article
- Testosterone Use in Adolescent Males: Current Practice and Unmet Needs.Journal of the Endocrine Society · 2021Review
- Morbidity in Klinefelter syndrome and the effect of testosterone treatment.American journal of medical genetics. Part C, Seminars in medical genetics · 2020Review
- High prevalence of cardiometabolic risk features in adolescents with 47,XXY/Klinefelter syndrome.American journal of medical genetics. Part C, Seminars in medical genetics · 2020Article
- Early neurodevelopmental and medical profile in children with sex chromosome trisomies: Background for the prospective eXtraordinarY babies study to identify early risk factors and targets for intervention.American journal of medical genetics. Part C, Seminars in medical genetics · 2020Review
- Sex chromosome aneuploidies in 2020-The state of care and research in the world.American journal of medical genetics. Part C, Seminars in medical genetics · 2020Article
- Minipuberty in Klinefelter syndrome: Current status and future directions.American journal of medical genetics. Part C, Seminars in medical genetics · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
contextBoys with XXY have greater adiposity and a higher risk of cardiovascular disease. Infants with XXY have lower testosterone concentrations than typical boys, but no studies have evaluated adiposity in infants with XXY or the physiologic effects of giving testosterone replacement.
objectiveTo determine the effect of testosterone on body composition in infants with XXY.
designProspective, randomized trial.
settingTertiary care pediatric referral center.
participants20 infants 6 to 15 weeks of age with 47,XXY.
interventionTestosterone cypionate 25 mg intramuscularly monthly for three doses vs no treatment.
main outcome measuresDifference in change in adiposity (percent fat mass
resultsThe increase in percent fat mass (%FM)
conclusionsAdiposity of untreated infants was 15% greater than that of male controls by 5 months of age. Testosterone treatment for infants with XXY resulted in positive changes in body composition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.