ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2019
The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- The Potential Role of Lung-Protective Ventilation in Preventing Postoperative Delirium in Elderly Patients Undergoing Prone Spinal Surgery: A Preliminary Study.Medical science monitor : international medical journal of experimental and clinical research · 2020Trial
- Article
- Plasma and cerebrospinal fluid inflammation and the blood-brain barrier in older surgical patients: the Role of Inflammation after Surgery for Elders (RISE) study.Journal of neuroinflammation · 2021Article
- Association of CSF Alzheimer's disease biomarkers with postoperative delirium in older adults.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- A New Severity Scoring Scale for the 3-Minute Confusion Assessment Method (3D-CAM).Journal of the American Geriatrics Society · 2020Article
- Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Preoperative red cell distribution width predicts postoperative cognitive dysfunction after coronary artery bypass grafting.Bioscience reports · 2020Observational
- The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
25 authors.
Funding
Abstract
introductionThe Role of Inflammation after Surgery for Elders study correlates novel inflammatory markers measured in blood, cerebrospinal fluid (CSF) assays, and [
methodsThis study involved a prospective cohort design with patients who underwent elective hip and knee arthroplasty under spinal anesthesia. Sixty-five adults participated with their family members. Inflammatory biomarker assays were measured preoperatively on day 1 and postoperatively at one month.
resultsOn average, participants were 75 years old, and 72% were female. 54% underwent total knee arthroplasty, and 46% underwent total hip arthroplasty. The mean Modified Mini-Mental State (3MS) Examination score was 89.3; four patients (6%) scored ≤77 points. Plasma assays were completed in 63 (97%) participants, cerebrospinal fluid assays in 61 (94%), and PET imaging in 44 (68%). DISCUSSION: This complex study presents an innovative effort to correlate peripheral and central inflammatory biomarkers before and after major surgery in older adults. Strengths include collecting concurrent blood, cerebrospinal fluid, and positron-emission tomography with detailed clinical characterization of delirium, cognition, and functional status.
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