ArticleFrontiers in pediatrics2019
Kawasaki Disease Complicated With Macrophage Activation Syndrome: Case Reports and Literature Review.
Article in Frontiers in pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 30 citations in OpenAlex.
- Retrospective study: clinical analysis of Kawasaki disease complicated with macrophage activation syndrome.Italian journal of pediatrics · 2026Article
- 2016 sJIA-MAS criteria and a step-up therapeutic approach in KD-MAS: insights from a combined cohort and literature review.RMD open · 2026Review
- Intravenous Immunoglobulin Resistant Incomplete Kawasaki Disease in a 4-Month-Old Infant: A Case Report.Clinical case reports · 2026Article
- Thrombo-inflammation and Rethinking the Role of Aspirin in Kawasaki Disease.Current rheumatology reports · 2026Review
- Emergency in pediatric rheumatology: a narrative review.Frontiers in medicine · 2026Review
- Prediction nomogram of serum interferon-γ enable early identification of macrophage activation syndrome in children with Kawasaki disease.Clinical rheumatology · 2026Article
- Add in a virus: four cases of severe Kawasaki disease and concurrent adenovirus infection.BMC pediatrics · 2025Article
- Macrophage Activation Syndrome in Kawasaki Disease: Insights from a Systematic Literature Review on Diagnosis, Clinical Features, and Treatment.Children (Basel, Switzerland) · 2025Review
- Atypical Kawasaki disease with giant coronary artery aneurysms in a 2-month-old boy: a case report.Journal of medical case reports · 2024Article
- Kawasaki Disease-Associated Cytokine Storm Syndrome.Advances in experimental medicine and biology · 2024Review
- Heterogeneity of macrophage activation syndrome and treatment progression.Frontiers in immunology · 2024Review
- [Clinical features of Kawasaki disease complicated by macrophage activation syndrome: an analysis of 27 cases].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
- Efficacy of Anakinra on Multiple Coronary Arteries Aneurysms in an Infant with Recurrent Kawasaki Disease, Complicated by Macrophage Activation Syndrome.Children (Basel, Switzerland) · 2022Article
- Pediatric expert consensus on the application of glucocorticoids in Kawasaki disease.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Importance of Serum Ferritin Level for Early Diagnosis and Differentiation in Patients with Kawasaki Disease with Macrophage Activation Syndrome.Children (Basel, Switzerland) · 2021Article
- CLINICAL-EPIDEMIOLOGICAL RELATION BETWEEN SARS-COV-2 AND KAWASAKI DISEASE: AN INTEGRATIVE LITERATURE.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2021Review
- Long-term follow-up of coronary artery lesions in children in Kawasaki syndrome.European journal of pediatrics · 2021Observational
- Predictive Value of the Systemic Immune-Inflammation Index for Intravenous Immunoglobulin Resistance and Cardiovascular Complications in Kawasaki Disease.Frontiers in cardiovascular medicine · 2021Article
- Kawasaki Disease and Systemic Juvenile Idiopathic Arthritis - Two Ends of the Same Spectrum.Frontiers in pediatrics · 2021Article
- Macrophage activation syndrome in children with Kawasaki disease: diagnostic and therapeutic approaches.World journal of pediatrics : WJP · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrophage activation syndrome (MAS) is a rare and severe complication of Kawasaki disease (KD). The clinical feature, early diagnosis and treatment options, and prognosis need to be further determined in patients with KD complicated with MAS. In this report, we retrospectively analyzed three KD patients complicated with MAS who were treated in pediatric intensive care units (PICU) and reviewed the relevant literatures. We find that being male, being age over 2 years old, incomplete KD, intravenous immunoglobulin (IVIG) non-responder, or persistent fever greater than 10 days are all highly associated with occurrence of MAS. Additional work-ups should be performed promptly in patient with above predisposing factors to rule out complication of MAS. Patients with KD complicated with MAS are at a higher risk of having coronary artery involvement or aneurysm formation, which can be reversed with timely treatment. Early identification and prompt treatment are key points for improving the prognosis of KD patients complicated with MAS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.