Evidence map›Paper›PMID 31737574›Full record

ArticleFrontiers in cellular and infection microbiology2019

Sertraline Delivered in Phosphatidylserine Liposomes Is Effective in an Experimental Model of Visceral Leishmaniasis.

Maiara Maria Romanelli, Thais Alves da Costa-Silva, Edezio Cunha-Junior, Daiane Dias Ferreira, Juliana M Guerra, Andres Jimenez Galisteo, Erika Gracielle Pinto, Leandro R S Barbosa, Eduardo Caio Torres-Santos, Andre Gustavo Tempone

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Metabolic Pathways ofPharmaceutics · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Maiara Maria RomanelliCentre for Parasitology and Mycology, Instituto Adolfo Lutz, São Paulo, Brazil.
Thais Alves da Costa-SilvaCentre for Parasitology and Mycology, Instituto Adolfo Lutz, São Paulo, Brazil.
Edezio Cunha-JuniorFundação Oswaldo Cruz, Instituto Oswaldo Cruz, Pavilhão Leonidas Deane, Laboratório de Bioquímica de Tripanosomatídeos, Rio de Janeiro, Brazil.
Daiane Dias FerreiraCentre for Parasitology and Mycology, Instituto Adolfo Lutz, São Paulo, Brazil.
Juliana M GuerraCentre for Pathology, Instituto Adolfo Lutz, São Paulo, Brazil.
Andres Jimenez GalisteoFaculdade de Medicina, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, Brazil.
Erika Gracielle PintoDrug Discovery Unit, Life Sciences, University of Dundee, Dundee, Scotland.
Leandro R S BarbosaInstituto de Física da Universidade de São Paulo, Cidade Universitária, São Paulo, Brazil.
Eduardo Caio Torres-SantosFundação Oswaldo Cruz, Instituto Oswaldo Cruz, Pavilhão Leonidas Deane, Laboratório de Bioquímica de Tripanosomatídeos, Rio de Janeiro, Brazil.
Andre Gustavo TemponeCentre for Parasitology and Mycology, Instituto Adolfo Lutz, São Paulo, Brazil.
Instituto Adolfo Lutz · BRFundação Oswaldo Cruz · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversidade de São Paulo · BRUniversity of Dundee · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liposomes containing phosphatidylserine (PS) has been used for the delivery of drugs into the intramacrophage milieu.

Indexed as

LiposomesPhosphatidylserinesAnimalsAntiprotozoal AgentsDisease Models, AnimalDose-Response Relationship, DrugFemaleImmunomodulationLeishmania donovaniLeishmaniasis, VisceralLiverMacrophagesMiceMice, Inbred BALB CSertralineSpleenAntiprotozoal AgentsLiposomesPhosphatidylserinesSertralinedrug deliverydrug repurposingleishmanialiposomesneglected diseasessertraline

Identifiers

PMID31737574
PMCPMC6828611
OpenAlexW2982420026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.