ReviewCardiovascular diagnosis and therapy2019
Folate supplementation for prevention of congenital heart defects and low birth weight: an update.
Review in Cardiovascular diagnosis and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- A Silent Epidemic of Congenital Anomalies and Its Predictors Among Newborns in Ethiopia: A Systematic Review and Meta-Analysis.Public health reviews · 2026Pooled it
- Prevalence and associated factors of congenital anomalies in Ethiopia: A systematic review and meta-analysis.PloS one · 2024Pooled it
- High prevalence of congenital heart disease among hospitalized neonates in northwestern Tanzania; implications of maternal and environmental factors.International journal of cardiology. Congenital heart disease · 2026Article
- Management of Lithium in Pregnancy and Lactation: An Individualized Approach.Current psychiatry reports · 2026Review
- DNA Methylation and Its Role in Personalized Nutrition: Mechanisms, Clinical Insights, and Future Perspectives.International journal of molecular sciences · 2026Review
- Micronutrients in Obstetrics and Gynecology: Mini-Review Article.Journal of obstetrics and gynaecology of India · 2025Review
- Uncovering the hidden hunger in translational research for periconceptional folic acid awareness among health care providers.Journal of family medicine and primary care · 2025Article
- The relationship between the maternal consumption of barberry, saffron, pickled vegetables, and tea and the odds of congenital anomalies in Iranian children under 10 years of age: A case-control study.Journal of education and health promotion · 2025Article
- Folic acid supplementation on congenital heart disease and its dual character.Current research in pharmacology and drug discovery · 2025Review
- Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring.JAMA network open · 2024Article
- Dietary Patterns of Pregnant Women and Their Association with Diet Quality Measures: A Comparative Analysis.Nutrients · 2024Article
- Epigenetic Genome Modifications during Pregnancy: The Impact of Essential Nutritional Supplements on DNA Methylation.Nutrients · 2024Review
- Advances in DNA methylation of imprinted genes and folic acid regulation of growth and development.Epigenomics · 2024Review
- Advancing nutrition science to meet evolving global health needs.European journal of nutrition · 2023Article
- Excess folic acid intake increases DNA de novo point mutations.Cell discovery · 2023Article
- Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders.Current cardiology reviews · 2023Article
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- B Vitamins: Functions and Uses in Medicine.The Permanente journal · 2022Review
- In Vitro Toxicological Profile of Labetalol-Folic Acid/Folate Co-Administration in H9c2(2-1) and HepaRG Cells.Medicina (Kaunas, Lithuania) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Women planning a pregnancy and pregnant women in the first trimester are recommended to use folate-containing supplements in order to prevent neural tube defects. The prevention of many cases of neural tube defects with folic acid is evident from meta-analysis, randomized controlled trials (RCTs), observational studies in humans and experimental evidence in animals. However, folate supplementation in pregnant women or a higher maternal folate status has been shown to be protective against other adverse birth outcomes such as congenital heart defects, low birth weight, and preterm birth. Additionally, infants and children with congenital heart defects often show disorders in folate metabolism (low folate, higher homocysteine, or low vitamin B12). Maternal genotype for several folate metabolizing genes has shown associations with the risk of having a child with congenital heart defect. There is some evidence that folate supplementation could have differential effects on sub-types of congenital heart defects, but it is not clear whether the prevention time window is the same as for neural tube defects. Some studies proposed a high dose of folic acid (in mg/d) to prevent congenital heart defects in women with a high global risk (such as those with diabetes or obesity). There are currently no RCTs to support that doses of folic acid in mg range are more effective than the currently recommended 400-800 µg/d taken at least 2-3 months before conception until the end of the first trimester.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.