Evidence map›Paper›PMID 31737529›Full record

ArticleCardiovascular diagnosis and therapy2019

Hemostatic abnormalities in adult patients with Marfan syndrome.

Katharina T I Kornhuber, Heide Seidel, Claudia Pujol, Christian Meierhofer, Franz Röschenthaler, Axel Pressler, Alexander Stöckl, Nicole Nagdyman, Rhoia C Neidenbach, Philipp von Hundelshausen and 5 more

Open access · diamondAbstract read
In one paragraph

Article in Cardiovascular diagnosis and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. D-dimer in Marfan syndrome: effect of obstructive sleep apnea induced blood pressure surges.American journal of physiology. Heart and circulatory physiology · 2022
    Trial
  2. Article
  3. Blood Platelets as an Important but Underrated Circulating Source of TGFβ.International journal of molecular sciences · 2021
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Katharina T I KornhuberDepartment of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Munich, Germany.
Heide SeidelDepartment of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Munich, Germany.
Claudia PujolDepartment of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Munich, Germany.
Christian MeierhoferDepartment of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Munich, Germany.
Franz RöschenthalerInstitute of Laboratory Medicine, German Heart Center Munich, Technical University Munich, Munich, Germany.
Axel PresslerOutpatients' Clinic for Prevention, Rehabilitation and Sports Medicine, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany.
Alexander StöcklDepartment of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Munich, Germany.
Nicole NagdymanDepartment of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Munich, Germany.
Rhoia C NeidenbachDepartment of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Munich, Germany.
Philipp von HundelshausenInstitute for Cardiovascular Prevention, Faculty of Medicine, Ludwig Maximilian University, Munich, Germany.
Martin HalleOutpatients' Clinic for Prevention, Rehabilitation and Sports Medicine, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany.
Stefan HoldenriederInstitute of Laboratory Medicine, German Heart Center Munich, Technical University Munich, Munich, Germany.
Peter EwertDepartment of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Munich, Germany.
Harald KaemmererDepartment of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Munich, Germany.
Michael HauserDepartment of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Munich, Germany.
Deutsches Herzzentrum München · DEKlinikum rechts der Isar · DELudwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAortic root ectasia might induce hemostatic disorders in patients with Marfan syndrome (MFS) via altered blood flow and rheology. The aim of this study was to explore the hemostasis in patients with MFS compared with healthy controls.

methodsIn this cross-sectional case-control study we included patients with verified MFS (n=51) and sex- and age-matched healthy controls (n=50). Main criteria were the aortic root in echocardiography and cardiac magnetic resonance imaging (MRI), and the coagulation status.

resultsWhen compared with healthy controls, patients with MFS showed significantly increased diameters of the aortic roots (43.0±7.72

conclusionsIn conclusion, our study reveals hemostatic deviations in patients with MFS. Further studies are necessary to understand the causal relationship and the exact pathomechanism.

Indexed as

aortic root dilatationcoagulationMarfan

Identifiers

PMID31737529
PMCPMC6837936
OpenAlexW2975213152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.