Evidence map›Paper›PMID 31737350›Full record

ReviewJournal of thoracic disease2019

Nutritional support in chronic obstructive pulmonary disease (COPD): an evidence update.

Peter F Collins, Ian A Yang, Yuan-Chin Chang, Annalicia Vaughan

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of thoracic disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07664111 (Effects of an 8-Week Ketogenic Dietary Intervention on Pulmonary Function, Systemic Inflammation, Body Composition, and Functional Exercise Capacity in Men With Mild-to-Moderate Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 78 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 10 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07664111 nacompletednot on this mapstarted 2026, after this paper: background citation

Effects of an 8-Week Ketogenic Dietary Intervention on Pulmonary Function, Systemic Inflammation, Body Composition, and Functional Exercise Capacity in Men With Mild-to-Moderate Chronic Obstructive Pulmonary Disease: A Pilot Randomized Controlled Trial

TypeinterventionalSponsorAgri Ibrahim Cecen UniversityRan2026 to 2026Enrolled34ConditionsChronic Obstructive Pulmonary Disease (COPD)ArmsKetogenic diet, Standard Dietary Advice
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 10 syntheses or guidelines pooled it, 145 citations in OpenAlex.

  1. Multimodal interventions for cachexia management.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Frailty in COPD: Clinical Impact, Diagnosis, Biomarkers, and Management Strategies.International journal of chronic obstructive pulmonary disease · 2025
    Pooled it
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  7. Guideline
  8. Pooled it
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  19. Facilitating interprofessional collaboration for effective care transitions of a patient with chronic obstructive pulmonary disease.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Review
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Peter F CollinsSchool of Human Movement and Nutrition Science, Faculty of Medicine, The University of Queensland, Brisbane, Australia.
Ian A YangUniversity of Queensland Thoracic Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, Australia.
Yuan-Chin ChangUniversity of Queensland Thoracic Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, Australia.
Annalicia VaughanUniversity of Queensland Thoracic Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, Australia.
Prince Charles Hospital · AUUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) primarily affects the lungs but due to the accompanying chronic systematic inflammation and the symptoms associated with the disease there are many extrapulmonary effects which include complex physical and metabolic adaptations. These changes have been associated with reduced exercise capacity, increased nutritional requirements, altered metabolic processes and compromised nutritional intake. As a result, nutritional depletion in COPD is multi-faceted and can involve imbalances of energy (weight loss), protein (sarcopenia), and periods of markedly increased inflammation (pulmonary cachexia) which can increase nutritional losses. As a result, depletion of both fat-mass (FM) and fat-free mass (FFM) can occur. There is good evidence that nutritional support, in the form of oral nutritional supplements (ONS), can overcome energy and protein imbalances resulting in improved nutritional status and functional capacity. However, in order to treat the aetiology of sarcopenia, frailty and cachexia, it is likely that targeted multi-modal interventions are required to address energy and protein imbalance, specific nutrient deficiencies, reduced androgens and targeted exercise training. Furthermore, interventions taking a disease-course approach, are likely to hold the key to effectively managing the common and costly problem of nutritional depletion in COPD.

Indexed as

Chronic obstructive pulmonary disease (COPD)malnutritionnutrition support

Identifiers

PMID31737350
PMCPMC6831917
OpenAlexW2986720398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.