ArticleVeterinary research forum : an international quarterly journal2019
Leptospirosis and immune-mediated hemolytic anemia: A lethal association.
Article in Veterinary research forum : an international quarterly journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Article
- Stillbirth and fulminant postpartum haemolysis: COVID-19 or leptospirosis or both?BMJ case reports · 2023Article
- Article
- Acute leptospirosis in horses: A retrospective study of 11 cases (2015-2023).Journal of veterinary internal medicineArticle
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2 authors at 1 institution in 1 country.
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Abstract
Immune-mediated hemolytic anemia (IMHA) is a common cause of anemia in dogs. The immune aggression towards erythrocytes can be triggered by many pathological conditions such as infection, inflammatory disease or neoplasia. Upon ruling out any eliciting conditions, a diagnosis of the primary immune-mediated disease can be made. In this particular case of severe anemia (tested positive for circulating antibodies against red blood cells with flow cytometry), vector-borne diseases (which are a common cause of immunopathology in Mediterranean countries) were excluded, leptospirosis was not. This resulted in an unsuccessful immunosuppressive therapy with prednisone, two whole blood transfusions and ultimately death of the patient. Leptospirosis (confirmed positive in two tests, micro-agglutination test for antibodies and PCR for microbial DNA in urine), can mimic a primary IMHA and must be considered in its differential list of causes. A liver involvement, that included elevated serum activity of liver enzymes and increased serum bile acid was observed at the admission and suggested an etiopathogenesis other than a primary IMHA.
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