ArticleVeterinary research forum : an international quarterly journal2019
Effects of curcumin on canine semen parameters and expression of NOX5 gene in cryopreserved spermatozoa.
Article in Veterinary research forum : an international quarterly journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Synergistic protection of chilled canine spermatozoa by apigenin and N-acetylcysteine amide through enhanced antioxidant defense and mitochondrial function.BMC veterinary research · 2026Article
- Urolithin A improves motility, antioxidant defense, and mitochondrial function of chilled canine spermatozoa during 72-h liquid storage.Scientific reports · 2026Article
- Dose-dependent effects of curcumin on bacterial growth and sperm quality during refrigerated storage of equine epididymal sperm.Frontiers in veterinary science · 2026Article
- A review of sperm cryopreservation in the domestic dog and cat: part I, from science to clinic.Acta veterinaria Scandinavica · 2025Review
- Impact of Oxidative Stress and Antioxidants on Semen Quality in Dogs.Animals : an open access journal from MDPI · 2025Review
- Turmeric and Curcumin-Health-Promoting Properties in Humans versus Dogs.International journal of molecular sciences · 2023Review
- Calpain Regulates Reactive Oxygen Species Production during Capacitation through the Activation of NOX2 and NOX4.International journal of molecular sciences · 2023Article
- Curcumin Attenuates Damage to Rooster Spermatozoa Exposed to Selected Uropathogens.Pharmaceutics · 2022Article
- Assisted reproductive techniques for canines: preservation of genetic material in domestic dogs.The Journal of reproduction and development · 2022Article
- Male Infertility and Oxidative Stress: A Focus on the Underlying Mechanisms.Antioxidants (Basel, Switzerland) · 2022Review
- A comparative study of nutrient composition, bioactive properties and phytochemical characteristics ofFrontiers in nutrition · 2022Article
- Protective Effects of Curcumin on the Outcome of Cryopreservation in Human Sperm.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Cryoprotective Effects of Ergothioneine and Isoespintanol on Canine Semen.Animals : an open access journal from MDPI · 2021Article
- The Role of Selected Natural Biomolecules in Sperm Production and Functionality.Molecules (Basel, Switzerland) · 2021Review
- Overview on the Antioxidants, Egg Yolk Alternatives, and Mesenchymal Stem Cells and Derivatives Used in Canine Sperm Cryopreservation.Animals : an open access journal from MDPI · 2021Review
- Protective effects of curcumin on chromatin quality, sperm parameters, and apoptosis following testicular torsion-detorsion in mice.Clinical and experimental reproductive medicine · 2021Article
- Antioxidants in assisted reproductive technologies: An overview on dog, cat, and horse.Journal of advanced veterinary and animal research · 2021Review
- Antioxidants in Fish Sperm and the Potential Role of Melatonin.Antioxidants (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine seminal plasma contains antioxidant enzymes to protect sperm against internally generated ROS. These enzymes are removed from seminal plasma during the process of cryopreservation. The freezing/thawing process can cause some morphological and functional changes via ice crystallization and osmolality imbalance. The present study was conducted to evaluate the effects of curcumin supplementation on sperm total count, motility, progressive motility, viability, morphology, total antioxidant capacity (TAC), DNA integrity and NOX5 gene expression of dog frozen semen. The pooled semen was allocated to fresh (Group 1) and frozen (Group 2) controls, curcumin (2.50 mM) (Group 3) and curcumin (5.00 mM), (Group 4). Sperm parameters including total sperm count, morphology, motility, progressive motility, sperm concentration and DNA integrity in addition to TAC were evaluated in fresh and frozen-thawed semen samples. Real-time RT-PCR was used to investigate NOX5 and GADPH (reference gene) genes expressions. Curcumin at 2.50 mM provided a greater protective effect on the DNA integrity compared to 5.00 mM and control groups. TAC was significantly higher in 2.50 mM group than other groups. NOX5 gene expression in curcumin 2.50 mM was higher than 5.00 mM group. In conclusion, curcumin seems to emolliate sperm parameters and to protect sperm against sperm reactive oxygen stress and increases NOX5 gene expression.
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