Evidence map›Paper›PMID 31737211›Full record

ArticleAmerican journal of translational research2019

LINC01234 promotes multiple myeloma progression by regulating miR-124-3p/GRB2 axis.

Xueyan Chen, Yin Liu, Zihua Yang, Jiang Zhang, Shaoqian Chen, Jing Cheng

Open access · greenAbstract read
In one paragraph

Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  4. Long non‑coding RNAs in multiple myeloma (Review).International journal of oncology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xueyan ChenDepartment of Clinical Laboratory, The People's Hospital of Longhua Shenzhen 518109, Guangdong Province, China.
Yin LiuDepartment of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080, Guangdong Province, China.
Zihua YangDepartment of Clinical Laboratory, Shenzhen People's Hospital, 2nd Clinical Medical College of Jinan University Shenzhen 518020, Guangdong Province, China.
Jiang ZhangDepartment of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080, Guangdong Province, China.
Shaoqian ChenDepartment of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080, Guangdong Province, China.
Jing ChengDepartment of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080, Guangdong Province, China.
Sun Yat-sen University · CNShenZhen People’s Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LncRNA is gradually considered as a vital regulator in various physiological and pathological processes. Recently, the role of LINC01234 in several cancers has been reported. However, the function and underlying regulatory mechanism of LINC01234 in multiple myeloma (MM) remain unclear. Our results indicated that LINC01234 was over-expressed in tumor tissues of MM patients, and LINC01234 down-regulation remarkably inhibited cell proliferation, cycle progression and promoted cell apoptosis in MM cells. Mechanistic studies revealed that LINC01234 could sponge miR-124-3p and decreased its expression, thereby up-regulated the protein level of miR-124-3p's targets growth factor receptor-bound protein 2 (GRB2). Additionally,

Indexed as

cell cyclecell proliferationGRB2LINC01234miR-124-3pMultiple myeloma

Identifiers

PMID31737211
PMCPMC6834521
OpenAlexW2996650031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.