ArticleAmerican journal of translational research2019
High-risk HPV E6/E7 mRNA in situ hybridization in endocervical glandular neoplasia: performance compared with p16
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Optimization of RNAscope for HPV mRNA detection in liquid-based cervical cytology samples.Frontiers in oncology · 2026Article
- Co-expression of SOX2 and HR-HPV RISH predicts poor prognosis in small cell neuroendocrine carcinoma of the uterine cervix.BMC cancer · 2021Article
- Evaluation of human papillomavirus (HPV) prediction using the International Endocervical Adenocarcinoma Criteria and Classification system, compared to p16 immunohistochemistry and HPV RNA in-situ hybridization.Journal of pathology and translational medicine · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHR-HPV E6/E7 mRNA in situ hybridization (HR-HPV RISH) can detect HPV-driven endocervical glandular neoplasia. Our aim was to compare its diagnostic performance with the conventional p16
methodsHR-HPV RISH and IHC were performed in normal cervix (n = 70), reactive cervix (n = 60), adenocarcinoma in situ (AIS) (n = 92), endocervical adenocarcinoma (ECA) and adenosquamous carcinoma (n = 21) samples (n = 163). The sensitivities and specificities of the three markers were compared in the benign, AIS, HPV-associated adenocarcinoma (HPVA) and non HPV-associated adenocarcinoma (NHPVA) samples, and in 39 endocervical curettage specimens containing endometrial and HPV-associated neoplastic glands. Finally, the inter-observer agreement rate for the three markers were calculated.
resultsThe sensitivities of HR-HPV RISH, P16
conclusionsHR-HPV RISH is highly sensitive and specific for HPV-driven endocervical glandular neoplasia compared to p16
Indexed as
Identifiers
31737201PMC6834507W2996884276What OpenQuestion holds
Registered trials
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