ArticleOxidative medicine and cellular longevity2019
Indigo Naturalis Suppresses Colonic Oxidative Stress and Th1/Th17 Responses of DSS-Induced Colitis in Mice.
Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Indigo naturalis for inflammatory bowel disease: evidence from animal studies and molecular mechanisms.Frontiers in pharmacology · 2025Pooled it
- EngineeredFrontiers in immunology · 2026Article
- Compound spleen-tonifying composition alleviates dextran sulfate sodium-induced ulcerative colitis in rats.World journal of gastrointestinal surgery · 2025Article
- Review
- Efficacy of active ingredients in Qingdai on ulcerative colitis: a network pharmacology-based evaluation.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- Activation of P2Y1R impedes intestinal mucosa repair during colitis.International journal of biological sciences · 2023Article
- Article
- Tuberous Sclerosis Complex 1 Deficiency in Macrophages Promotes Unclassical Inflammatory Response to LipopolysaccharideAging and disease · 2022Article
- Oral dextran sulfate sodium administration induces peripheral spondyloarthritis features in SKG mice accompanied by intestinal bacterial translocation and systemic Th1 and Th17 cell activation.Arthritis research & therapy · 2022Article
- Colon Expression of Chemokines and Their Receptors Depending on the Stage ofInternational journal of molecular sciences · 2022Article
- Traditional Chinese Medicine and Natural Products: Potential Approaches for Inflammatory Bowel Disease.Frontiers in pharmacology · 2022Review
- P2Y1R Ligation Suppresses Th17 Cell Differentiation and Alleviates Colonic Inflammation in an AMPK-Dependent Manner.Frontiers in immunology · 2022Article
- Ban-Lan-Gen Granule Alleviates Dextran Sulfate Sodium-Induced Chronic Relapsing Colitis in Mice via Regulating Gut Microbiota and Restoring Gut SCFA Derived-GLP-1 Production.Journal of inflammation research · 2022Article
- Trypsin inhibitor LH011 inhibited DSS-induced mice colitisFrontiers in pharmacology · 2022Article
- Extracts of Waste from Poplar Wood Processing Alleviate Experimental Dextran Sulfate-Induced Colitis by Ameliorating Oxidative Stress, Inhibiting the Th1/Th17 Response and Inducing Apoptosis in Inflammatory Lymphocytes.Antioxidants (Basel, Switzerland) · 2021Article
- Supplementation With Chinese Medicinal Plant Extracts FromFrontiers in cellular and infection microbiology · 2021Article
- Caffeic Acid Supplement Alleviates Colonic Inflammation and Oxidative Stress Potentially Through Improved Gut Microbiota Community in Mice.Frontiers in microbiology · 2021Article
- Regulation of the intestinal microbiota: An emerging therapeutic strategy for inflammatory bowel disease.World journal of gastroenterology · 2020Review
- Anti-inflammatory properties of uvaol on DSS-induced colitis and LPS-stimulated macrophages.Chinese medicine · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Indigo naturalis (also known as Qing-dai, or QD), a traditional Chinese medicine, has been widely used as an anticolitis regimen in the clinical practice of Chinese medicine. However, the precise mechanisms behind its efficacy remain unknown. We investigated the protective effects and associated molecular mechanisms of QD in DSS-induced colitis in mice. We found that QD administration attenuated DSS-induced colon shortening, tissue damage, and the disease activity index during the onset of colitis. Moreover, QD administration significantly suppressed colonic MPO activity and increased the activities of colonic T-SOD, CAT, and GSH-Px, as well the expression of p-AMPK and Nrf-2 in colon tissues of colitic mice. In addition, QD was capable of reducing the colonic Th1 and Th17 cell cytokines, the frequencies of Th1 and Th17 cells, and the phosphorylation of p-STAT1 and p-STAT3 in the mesenteric lymph nodes of colitic mice. An
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.