Evidence map›Paper›PMID 31737126›Full record

Observational studyDisease markers2019

Vitamin D Deficiency Predicts Poor Clinical Outcomes in Heart Failure Patients Undergoing Cardiac Resynchronization Therapy.

P Perge, A M Boros, L Gellér, I Osztheimer, Sz Szilágyi, T Tahin, A Apor, K V Nagy, E Zima, L Molnár and 2 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

P PergeHeart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest 1122, Hungary.
A M BorosHeart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest 1122, Hungary.
L GellérHeart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest 1122, Hungary.
I OsztheimerHeart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest 1122, Hungary.
Sz SzilágyiHeart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest 1122, Hungary.
T TahinHeart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest 1122, Hungary.
A AporHeart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest 1122, Hungary.
K V NagyHeart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest 1122, Hungary.
E ZimaHeart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest 1122, Hungary.ORCID https://orcid.org/0000-0001-5132-6009
L MolnárHeart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest 1122, Hungary.
B MerkelyHeart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest 1122, Hungary.ORCID https://orcid.org/0000-0001-6514-0723
G SzéplakiHeart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest 1122, Hungary.
Semmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsResynchronization therapy (CRT) improves mortality and induces reverse remodeling in heart failure (HF) patients with reduced ejection fraction and wide QRS. Nonetheless, some patients do not improve despite the optimal medical therapy and right indications for device implantation. Therefore, finding biomarkers suitable for identification of those patients is crucial. Vitamin D plays a classic hormonal role in the regulation of bone metabolism and also has physiological functions in wide range of nonskeletal tissues. Based on recent studies, low levels of vitamin D seem to directly contribute to pathogenesis and worsening of HF. We planned to assess the role of vitamin D levels on clinical outcomes of HF patients undergoing CRT. METHODS AND

resultsWe enrolled 136 HF patients undergoing CRT. Total plasma vitamin D levels were measured at baseline and 6 months later. Primary endpoint was 5-year all-cause mortality; secondary endpoint was lack of good clinical response, defined as less than 15% increase of left ventricular ejection fraction after six months. During follow-up, 58 patients reached the primary, and 45 patients reached the secondary endpoint. Vitamin D levels less than 24.13 ng/mL predicted 5-year mortality (

conclusionOur study showed that vitamin D deficiency has a significant impact in heart failure patients; it is an independent predictor of lack of midterm clinical response and long-term mortality in patients undergoing CRT. Therefore, monitoring vitamin D status of heart failure patients could be of clinical significance.

Indexed as

Cardiac Resynchronization TherapyAgedBiomarkersFemaleHeart FailureHumansMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsProportional Hazards ModelsProspective StudiesSunlightTreatment OutcomeVentricular Dysfunction, LeftVitamin DBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Vitamin D

Identifiers

PMID31737126
PMCPMC6815629
OpenAlexW2979403718

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.