Evidence map›Paper›PMID 31736786›Full record

ArticleFrontiers in physiology2019

MiR-29 Regulates

Yu-Han Hung, Matt Kanke, Catherine Lisa Kurtz, Rebecca L Cubitt, Rodica P Bunaciu, Liye Zhou, Phillip J White, Kasey C Vickers, Mohammed Mahmood Hussain, Xiaoling Li and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Yu-Han HungDepartment of Biomedical Sciences, Cornell University, Ithaca, NY, United States.
Matt KankeDepartment of Biomedical Sciences, Cornell University, Ithaca, NY, United States.
Catherine Lisa KurtzDepartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
Rebecca L CubittDepartment of Biomedical Sciences, Cornell University, Ithaca, NY, United States.
Rodica P BunaciuDepartment of Biomedical Sciences, Cornell University, Ithaca, NY, United States.
Liye ZhouDiabetes and Obesity Research Center, NYU Winthrop Hospital, Mineola, NY, United States.
Phillip J WhiteDuke Molecular Physiology Institute, Duke University, Durham, NC, United States.
Kasey C VickersDepartment of Medicine, Vanderbilt University, Nashville, TN, United States.
Mohammed Mahmood HussainDiabetes and Obesity Research Center, NYU Winthrop Hospital, Mineola, NY, United States.
Xiaoling LiLaboratory of Signal Transduction, National Institute of Environmental Health Sciences, Durham, NC, United States.
Praveen SethupathyDepartment of Biomedical Sciences, Cornell University, Ithaca, NY, United States.
Cornell University · USWinthrop-University Hospital · USDuke University · USNational Institute of Environmental Health Sciences · USUniversity of North Carolina at Chapel Hill · USVanderbilt University · US

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
Non-coding RNA & Bioinformatics CoreP01HL116263 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LINTON, MACRAE F · 2014 to 2025
$24.7M
Role of IL-10 in APC Regulation of Protective vs. Pathogenic T Cell Responses toP01DK094779 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SARTOR, RYAN B · 2013 to 2023
$17.9M
HDL-microRNA Intercellular Communication in AtherosclerosisR01HL128996 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI VICKERS, KASEY C · 2015 to 2019
$2.3M
Molecular and Biological Functions of miR-29 in Lipid HomeostasisR01DK105965 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SETHUPATHY, PRAVEEN · 2016 to 2019
$1.4M
NHLBI NIH HHS P01 HL116263NHLBI NIH HHS R01 HL128996NIDDK NIH HHS P01 DK094779NIDDK NIH HHS P30 DK056350NIDDK NIH HHS R01 DK105965
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are known regulators of lipid homeostasis. We recently demonstrated that miR-29 controls the levels of circulating cholesterol and triglycerides, but the mechanisms remained unknown. In the present study, we demonstrated that systemic delivery of locked nucleic acid inhibitor of miR-29 (LNA29) through subcutaneous injection effectively suppresses hepatic expression of miR-29 and dampens

Indexed as

lipogenesislivermicroRNA (miRNA)miR-29Sirtuin 1 (Sirt1)

Identifiers

PMID31736786
PMCPMC6828850
OpenAlexW2981619481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.