ArticleFrontiers in physiology2019
Increased Hemoglobin Oxygen Affinity With 5-Hydroxymethylfurfural Supports Cardiac Function During Severe Hypoxia.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Intermittent Hypoxia Associated with Sleep Apnea Disrupts Microvascular Hemodynamics and Oxygen Delivery.Communications biology · 2026Article
- Hemoglobin binders reduce inflammation and tissue injury from hemolysis in venovenous extracorporeal circulation.Blood advances · 2026Article
- Effects of drugs on the oxygen dissociation curve-a scoping review.European journal of clinical pharmacology · 2025Article
- Hemoglobin Variants as Targets for Stabilizing Drugs.Molecules (Basel, Switzerland) · 2025Review
- The antisickling agent, 5-hydroxymethyl-2-furfural: Other potential pharmacological applications.Medicinal research reviews · 2024Review
- Effect of Hb conformational changes on oxygen transport physiology.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Review
- High-molecular-weight linear polymers improve microvascular perfusion after extracorporeal circulation.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- X-ray crystallography and sickle cell disease drug discovery-a tribute to Donald Abraham.Frontiers in molecular biosciences · 2023Review
- The oxygen dissociation curve of blood in COVID-19-An update.Frontiers in medicine · 2023Review
- Solid-Phase Polymerization Using Anion-Exchange Resin Can Almost Completely Crosslink Hemoglobin to Prepare Hemoglobin-Based Oxygen Carriers.International journal of nanomedicine · 2023Article
- Muscle oxygenation during normoxic and hypoxic cycling exercise in humans with high-affinity haemoglobin.Experimental physiology · 2022Article
- Extracorporeal circulation impairs microcirculation perfusion and organ function.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- A LignocellulolyticJournal of fungi (Basel, Switzerland) · 2021Article
- Increased hemoglobin affinity for oxygen with GBT1118 improves hypoxia tolerance in sickle cell mice.American journal of physiology. Heart and circulatory physiology · 2021Article
- High-throughput determination of oxygen dissociation curves in a microplate reader-A novel, quantitative approach.Physiological reports · 2021Article
- Comprehensive Metabolomics and Network Pharmacology to Explore the Mechanism of 5-Hydroxymethyl Furfural in the Treatment of Blood Deficiency Syndrome.Frontiers in pharmacology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Acclimatization to hypoxia or high altitude involves physiological adaptation processes, to influence oxygen (O
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.