Evidence map›Paper›PMID 31736764›Full record

ArticleFrontiers in pharmacology2019

Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A.

Muhammad Rafehi, Frank Faltraco, Johannes Matthaei, Thomas Prukop, Ole Jensen, Aileen Grytzmann, Felix G Blome, Ralf Günter Berger, Ulrich Krings, Stefan V Vormfelde and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  5. Review of Elevated Para-Cresol in Autism and Possible Impact on Symptoms.International journal of molecular sciences · 2025
    Review
  6. Alterations in tryptophan metabolism andFrontiers in medicine · 2024
    Article
  7. Article
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  9. Article
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Muhammad RafehiInstitute of Clinical Pharmacology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
Frank FaltracoInstitute of Clinical Pharmacology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
Johannes MatthaeiInstitute of Clinical Pharmacology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
Thomas PrukopInstitute of Clinical Pharmacology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
Ole JensenInstitute of Clinical Pharmacology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
Aileen GrytzmannInstitute of Clinical Pharmacology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
Felix G BlomeInstitute of Clinical Pharmacology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
Ralf Günter BergerInstitute of Food Chemistry, Leibniz University, Hannover, Germany.
Ulrich KringsInstitute of Food Chemistry, Leibniz University, Hannover, Germany.
Stefan V VormfeldeInstitute of Clinical Pharmacology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
Mladen V TzvetkovInstitute of Clinical Pharmacology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
Jürgen BrockmöllerInstitute of Clinical Pharmacology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
University of Göttingen · DEUniversitätsmedizin Göttingen · DELeibniz University Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tyramine, formed by the decarboxylation of tyrosine, is a natural constituent of numerous food products. As an indirect sympathomimetic, it can have potentially dangerous hypertensive effects.

Indexed as

biogenic amineCYP2D6MAOmonoamine oxidaseOCT1pressor responseSLC22A1tyramine

Identifiers

PMID31736764
PMCPMC6831736
OpenAlexW2982347208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.