Evidence map›Paper›PMID 31736705›Full record

ArticleFrontiers in neuroscience2019

Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain.

Jen-Hsiang T Hsiao, Sivaraman Purushothuman, Poul H Jensen, Glenda M Halliday, Woojin Scott Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Understanding coenzyme Q.Physiological reviews · 2024
    Review
  5. Review
  6. Article
  7. The genetic basis of multiple system atrophy.Journal of translational medicine · 2023
    Review
  8. Review
  9. Coenzyme Q10: Role in Less Common Age-Related Disorders.Antioxidants (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Jen-Hsiang T HsiaoBrain and Mind Centre and Central Clinical School, The University of Sydney, Sydney, NSW, Australia.
Sivaraman PurushothumanBrain and Mind Centre and Central Clinical School, The University of Sydney, Sydney, NSW, Australia.
Poul H JensenDepartment of Biomedicine, DANDRITE-Danish Research Institute of Translational Neuroscience, Aarhus University, Aarhus, Denmark.
Glenda M HallidayBrain and Mind Centre and Central Clinical School, The University of Sydney, Sydney, NSW, Australia.
Woojin Scott KimBrain and Mind Centre and Central Clinical School, The University of Sydney, Sydney, NSW, Australia.
University of Sydney · AUAarhus University · DKNeuroscience Research Australia · AUUNSW Sydney · AU

Funding

Brain Tissue Resource Centre for Alcohol ResearchR28AA012725 · NIAAA · UNIVERSITY OF SYDNEY · PI Greg Trevor Sutherland · 2012 to 2026
$7.0M
NIAAA NIH HHS R28 AA012725
6 · The paper itself

Abstract

Multiple system atrophy (MSA) is a progressive neurodegenerative disease clinically characterized by parkinsonism and cerebellar ataxia, and pathologically by oligodendrocyte α-synuclein inclusions. Genetic variants of COQ2 are associated with an increased risk for MSA in certain populations. Also, deficits in the level of coenzyme Q

Indexed as

ATPcerebellumcoenzyme Q10COQ2COQ7multiple system atrophyparkinsonian disorders

Identifiers

PMID31736705
PMCPMC6838639
OpenAlexW2983986116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.