Evidence map›Paper›PMID 31736454›Full record

ArticleEpidemiology and infection2019

Strategic investment in tuberculosis control in the Republic of Bulgaria.

T N Doan, T Varleva, M Zamfirova, M Tyufekchieva, A Keshelava, K Hristov, A Yaneva, B Gadzheva, S Zhang, S Irbe and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Epidemiology and infection, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Overlooked, dismissed, and downplayed: reversion ofEuropean respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

T N DoanDepartment of Medicine at The Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-5514-8518
T VarlevaPromotion and Prevention of Diseases and Addictions, Ministry of Health, Sofia, Bulgaria.
M ZamfirovaPromotion and Prevention of Diseases and Addictions, Ministry of Health, Sofia, Bulgaria.
M TyufekchievaPromotion and Prevention of Diseases and Addictions, Ministry of Health, Sofia, Bulgaria.
A KeshelavaPromotion and Prevention of Diseases and Addictions, Ministry of Health, Sofia, Bulgaria.
K HristovPromotion and Prevention of Diseases and Addictions, Ministry of Health, Sofia, Bulgaria.
A YanevaPromotion and Prevention of Diseases and Addictions, Ministry of Health, Sofia, Bulgaria.
B GadzhevaPromotion and Prevention of Diseases and Addictions, Ministry of Health, Sofia, Bulgaria.
S ZhangThe Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland.
S IrbeThe Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland.
R RagonnetDepartment of Medicine at The Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.
E S McBrydeDepartment of Medicine at The Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.
J M TrauerSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Ministry of Interior · BGThe Royal Melbourne Hospital · AUGlobal Fund to Fight AIDS, Tuberculosis and Malaria · CHMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As Bulgaria transitions away from Global Fund grant, robust estimates of the comparative impact of the various response strategies under consideration are needed to ensure sustained effectiveness of the tuberculosis (TB) programme. We tailored an established mathematical model for TB control to the epidemic in Bulgaria to project the likely outcomes of seven intervention scenarios. Under existing programmatic conditions projected forward, the country's targets for achieving TB elimination in the coming decades will not be achieved. No interventions under consideration were predicted to accelerate the baseline projected reduction in epidemiological indicators significantly. Discontinuation of the 'Open Doors' program and activities of non-governmental organisations would result in a marked exacerbation of the epidemic (increasing incidence in 2035 by 6-8% relative to baseline conditions projected forward). Changing to a short course regimen for multidrug-resistant TB (MDR-TB) would substantially decrease MDR-TB mortality (by 21.6% in 2035 relative to baseline conditions projected forward). Changing to ambulatory care for eligible patients would not affect TB burden but would be markedly cost-saving. In conclusion, Bulgaria faces important challenges in transitioning to a primarily domestically-financed TB programme. The country should consider maintaining currently effective programs and shifting towards ambulatory care to ensure program sustainability.

Indexed as

AdolescentAdultAgedAged, 80 and overBulgariaChildChild, PreschoolCost of IllnessHealth Care CostsHealth PlanningHumansIncidenceInfantInfant, NewbornMiddle AgedModels, BiologicalEnd TB targetsmathematical modellingtransmission dynamics

Identifiers

PMID31736454
PMCPMC6873158
OpenAlexW2985916723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.