ArticleAmerican journal of physiology. Renal physiology2020
WNK bodies cluster WNK4 and SPAK/OSR1 to promote NCC activation in hypokalemia.
Open access · bronzeAbstract read
In one paragraph
Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 62 citations in OpenAlex.
- The kidney distal tubule potassium switch, modern diet and hypertension.Nature reviews. Nephrology · 2026Review
- Personalized Sequential Nephron Blockade for Diuretic Resistance in Acute Decompensated Heart Failure: A Narrative Review for the Cardiorenal Clinician.Journal of personalized medicine · 2026Review
- Advances in mechanical force-induced adaptive responses and pathological transition of renal tubular epithelial cells.Frontiers in cell and developmental biology · 2026Review
- Mechanistic Target of Rapamycin Complex 1 in Distal Convoluted Tubule and Renal Potassium Handling.Journal of the American Society of Nephrology : JASN · 2025Article
- Calcium-binding protein 39 in with-no-lysine kinase signaling and the modulation of renal tubular transport.Current opinion in nephrology and hypertension · 2025Review
- KS-WNK1 augments the effects of dietary potassium intake on renal sodium chloride reabsorption.The Journal of clinical investigation · 2025Article
- Kidney-specific WNK1 amplifies kidney tubule responsiveness to potassium via WNK body condensates.The Journal of clinical investigation · 2025Article
- NRBP1 and TSC22D proteins affect distal convoluted tubule physiology through modulation of the WNK pathway.Science advances · 2025Article
- Article
- Potassium supplementation and depletion during development of salt-sensitive hypertension in male and female SS rats.JCI insight · 2025Article
- The evolving concepts of KS-WNK1 effect on NCC activity.American journal of physiology. Renal physiology · 2025Review
- Familial Hyperkalemic Hypertension.Comprehensive Physiology · 2024Review
- NRBP1 and TSC22D proteins impact distal convoluted tubule physiology through modulation of the WNK pathway.bioRxiv : the preprint server for biology · 2024Article
- ClC-Kb pore mutation disrupts glycosylation and triggers distal tubular remodeling.JCI insight · 2024Article
- Sodium Chloride Cotransporter in Hypertension.Biomedicines · 2024Review
- Distal convoluted tubule-specific disruption of the COP9 signalosome but not its regulatory target cullin 3 causes tubular injury.American journal of physiology. Renal physiology · 2024Article
- Deletion of KS-WNK1 promotes NCC activation by increasing WNK1/4 abundance.American journal of physiology. Renal physiology · 2024Article
- A New Phase for WNK Kinase Signaling Complexes as Biomolecular Condensates.Physiology (Bethesda, Md.) · 2024Review
- Kinase Scaffold Cab39 Is Necessary for Phospho-Activation of the Thiazide-Sensitive NCC.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Modifying Dietary Sodium and Potassium Intake: An End to the 'Salt Wars'?Hypertension (Dallas, Tex. : 1979) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 4 countries.
Martin N ThomsonDepartment of Anatomy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Catherina A CuevasDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
Tim M BewarderDepartment of Anatomy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Carsten DittmayerDepartment of Anatomy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Lauren N MillerDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
Jinge SiDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
Ryan J CorneliusDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.ORCID 0000-0002-1389-1493
Xiao-Tong SuDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
Chao-Ling YangDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
James A McCormickDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
Juliette HadchouelInstitut National de la Santé et de la Recherche Médicale, Paris Cardiovascular Research Center, Paris, France.
David H EllisonDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon.ORCID 0000-0003-2915-265X
Sebastian BachmannDepartment of Anatomy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Kerim MutigDepartment of Anatomy, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-9006-5112
Oregon Health & Science University · USCharité - Universitätsmedizin Berlin · DEInserm · FRSechenov University · RU
Funding
WNK Kinase Regulation of Thiazide-sensitive NaCl TransportR01DK051496 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI David Hoadley Ellison, CHAO-LING YANG · 1998 to 2026
$8.4MRole of Kir4.1 in Regulating NCC and ROMK in DCTR01DK054983 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID H, WANG, WENHUI · 2001 to 2020
$7.4MRegulation of sodium transport and blood pressure by SPAK/OSR1 kinasesR01DK098141 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI JAMES A MCCORMICK, Ujwal Shinde · 2014 to 2026
$4.2MRegulation of renal ion transport by the CUL3-WNK-SPAK pathwayR56DK117903 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI MCCORMICK, JAMES A · 2019 to 2019
$116kRenal Effects of AldosteroneI01BX002228 · VA · PORTLAND VA MEDICAL CENTER · PI ELLISON, DAVID H · 2014 to 2021
–BLRD VA I01 BX002228NIDDK NIH HHS R01 DK051496NIDDK NIH HHS R01 DK054983NIDDK NIH HHS R01 DK098141NIDDK NIH HHS R56 DK117903
Abstract
K
Indexed as
AnimalsFemaleHypokalemiaKcnj10 ChannelKidneyKidney Tubules, DistalMaleMiceMice, KnockoutPhosphorylationPotassiumPotassium Channels, Inwardly RectifyingProtein Serine-Threonine KinasesSignal TransductionSolute Carrier Family 12, Member 3Kcnj10 ChannelOXSR1 protein, mousePotassiumPotassium Channels, Inwardly RectifyingPrkwnk4 protein, mouseProtein Serine-Threonine KinasesSlc12a3 protein, mouseSolute Carrier Family 12, Member 3Stk39 protein, mousedistal convoluted tubuleKir4.1Na+-Cl− cotransporteroxidative stress-responsive kinase-1Ste20-related proline-alanine-rich kinaseWNK4WNK bodies
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.