ArticleInternational journal of geriatric psychiatry2020
Long-term dementia risk prediction by the LIBRA score: A 30-year follow-up of the CAIDE study.
Article in International journal of geriatric psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 4 of them syntheses that pooled it.
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Who cites it
69 citing papers in PubMed, 4 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Discriminative performance of externally validated dementia risk prediction models: a systematic review and meta-analysis.BMC medicine · 2026Pooled it
- Umbrella review and Delphi study on modifiable factors for dementia risk reduction.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Diminished Returns of Higher Parental Education on Cognition for Black Adults in Middle and Later Life.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Pooled it
- Multi-domain prognostic models used in middle-aged adults without known cognitive impairment for predicting subsequent dementia.The Cochrane database of systematic reviews · 2023Pooled it
- Quantifying dementia prevention potential in the FINGER randomized controlled trial using the LIBRA prevention index.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Trial
- Lifestyle for Brain health (LIBRA) score, cognition, brain volume, and dementia risk in the UK Biobank.GeroScience · 2026Article
- Article
- Associations of dementia polyexposure scores to Alzheimer's disease endophenotypes in a diverse population.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Attitudes Towards Brain Health and Dementia Risk Reduction Among Minoritised Ethnic Communities in the United Kingdom: A Cross-Sectional Survey Analysis.International journal of geriatric psychiatry · 2026Article
- Co-Designing a Digital Brain Health Intervention for Chinese Older Adults: A User-Centred Approach.Australasian journal on ageing · 2026Article
- Associations of the Lifestyle for Brain Health (LIBRA) index with cognitive functioning across adulthood: Variation by sex and socioeconomic status in the German National Cohort (NAKO).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The impact of socioeconomic status and lifestyle on cognitive aging and brain health: results from the LIFE-Adult-Study.Alzheimer's research & therapy · 2026Article
- The role of modifiable risk factors on the cerebral myelin content and cognition: findings from The Maastricht Study.GeroScience · 2026Article
- Socioeconomic differences in dementia risk, lifestyle, and relevant determinants of behavior.Journal of Alzheimer's disease : JAD · 2026Article
- Evaluating MRI correlates of lifestyle-based dementia risk reduction: Results from the AgeWell.de imaging study.Journal of Alzheimer's disease : JAD · 2026Article
- Associations of dementia polyexposure scores to Alzheimer's disease endophenotypes in diverse populations.medRxiv : the preprint server for health sciences · 2026Article
- The Lifestyle Intervention in memory clinics of General and academic Hospitals Trial (LIGHT): Rationale and study design of a randomized controlled trial to reduce modifiable dementia risk.Alzheimer's research & therapy · 2026Article
- External validation of dementia risk prediction models in the EPIC-Norfolk cohort: a UK-based cohort study.NPJ dementia · 2026Article
- Dementia risk prediction: A comparative analysis of the ANU-ADRI, CAIDE, CogDrisk, LIBRA, and LIBRA2 indices in the HUNT study.The journal of prevention of Alzheimer's disease · 2025Article
- Assessment of dementia risk scores in predicting mild cognitive impairment: A comparison of CogDrisk, CAIDE, LIBRA, and ANU-ADRI.The journal of prevention of Alzheimer's disease · 2025Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAs no causal treatment for dementia is available yet, the focus of dementia research is slowly shifting towards prevention strategies. Therefore, this study aimed to examine the predictive accuracy of the "LIfestyle for BRAin Health" (LIBRA) score, a weighted compound score of 12 modifiable risk and protective factors, for dementia and mild cognitive impairment (MCI) in midlife and late-life, and in individuals with high or low genetic risk based on presence of the apolipoprotein (APOE) ε4 allele.
methodsThe LIBRA score was calculated for participants from the Finnish Cardiovascular Risk Factors, Aging and Dementia (CAIDE) population-based study examined in midlife (n = 1024) and twice in late-life (n = 604) up to 30 years later. Diagnoses of MCI and dementia were made according to established criteria. Cox proportional hazards models were used to assess the association between LIBRA and risk of dementia and MCI in models adjusted for sex and education (age as timescale).
resultsHigher midlife LIBRA scores were related to higher risk of dementia (hazard ratio [HR] = 1.27; 95% confidence interval [CI], 1.13-1.43) and MCI (unadjusted model: HR = 1.12; 95% CI, 1.03-1.22) up to 30 years later. Higher late-life LIBRA scores were related to higher risk of MCI (HR = 1.11; 95% CI, 1.00-1.25), but not dementia (HR = 1.02; 95% CI, 0.84-1.24). Higher late-life LIBRA scores were related to higher dementia risk among apolipoprotein E (APOE) ε4 non-carriers.
conclusionsFindings emphasize the importance of modifiable risk and protective factors for dementia prevention.
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