Evidence map›Paper›PMID 31736048›Full record

ReviewFEBS letters2019

Immune evasion by adenoviruses: a window into host-virus adaptation.

Edson R A Oliveira, Marlene Bouvier

Abstract readReview
In one paragraph

Review in FEBS letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Adenoviral E3/49K: CD45-targeted immune evasion and therapeutic potential.Frontiers in cellular and infection microbiology · 2026
    Review
  9. Article
  10. Article
  11. Review
  12. Research progress on human adenovirus sepsis.Frontiers in pediatrics · 2025
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Adenovirus as a Vector and Oncolytic Virus.Current issues in molecular biology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Edson R A OliveiraDepartment of Microbiology and Immunology, University of Illinois at Chicago, IL, USA.
Marlene BouvierDepartment of Microbiology and Immunology, University of Illinois at Chicago, IL, USA.

Funding

Understanding ERAP molecular mechanism of MHC I antigen processingR01AI114467 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BOUVIER, MARLENE · 2017 to 2021
$2.0M
Subversion of MHC class I antigen presentation by viral immunomodulatory proteinsR01AI108546 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BOUVIER, MARLENE · 2014 to 2018
$2.0M
Uncovering the mechanism of immune evasion by species F adenovirusesR21AI135917 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BOUVIER, MARLENE · 2018 to 2019
$440k
NIAID NIH HHS R01 AI108546NIAID NIH HHS R01 AI114467NIAID NIH HHS R21 AI135917
6 · The paper itself

Abstract

Human adenoviruses (HAdVs) are widespread pathogens that cause a number of partially overlapping, species-specific infections associated with respiratory, urinary, gastrointestinal, and ocular diseases. The early 3 (E3) region of adenoviruses is highly divergent between different species, and it encodes a multitude of proteins with immunomodulatory functions. The study of genetic diversity in the E3 region offers a unique opportunity to gain insight into how the various HAdVs have evolutionarily adapted in response to the selection pressures exerted by host immune defenses. The objective of this review was to discuss subversion of host antiviral immune responses by HAdVs, with a focus on suppression of MHC class I antigen presentation, as a window into host-HAdV adaptation.

Indexed as

Immune EvasionAdenovirus E3 ProteinsAdenoviruses, HumanAdenovirus Infections, HumanAntigen PresentationEvolution, MolecularHistocompatibility Antigens Class IHost-Pathogen InteractionsHumansSelection, GeneticAdenovirus E3 ProteinsHistocompatibility Antigens Class IadenovirusE1A regionE3-19K proteinE3 regionhost immunityMHC class I antigen presentationviral immune evasion

Identifiers

PMID31736048
PMCPMC8034605

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.