Evidence map›Paper›PMID 31736012›Full record

ArticleFunctional & integrative genomics2020

Comprehensive analysis of the expression profile of circRNAs and their predicted protein-coding ability in the muscle of mdx mice.

Zubiao Song, Yanmei Liu, Xiaobo Fang, Mengshu Xie, Zhenyu Ma, Zhigang Zhong, Xuelin Feng, Weixi Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Functional & integrative genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. CircularRNA and Musculoskeletal Diseases.Advances in experimental medicine and biology · 2025
    Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. The Roles of CircRNAs in Regulating Muscle Development of Livestock Animals.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Zubiao SongDepartment of Neurology, the First Affiliated Hospital, Sun Yat-sen University, No 58, Zhongshan 2 Road, Guangzhou, 510080, Guangdong Province, People's Republic of China.
Yanmei LiuDepartment of Neurology, the First Affiliated Hospital, Sun Yat-sen University, No 58, Zhongshan 2 Road, Guangzhou, 510080, Guangdong Province, People's Republic of China.
Xiaobo FangDepartment of Neurology, the First Affiliated Hospital, Sun Yat-sen University, No 58, Zhongshan 2 Road, Guangzhou, 510080, Guangdong Province, People's Republic of China.
Mengshu XieDepartment of Rehabilitation, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, People's Republic of China.
Zhenyu MaDepartment of Neurology, the Second Affiliated Hospital, Guangzhou Medicine University, Guangzhou, Guangdong Province, People's Republic of China.
Zhigang ZhongDepartment of Neurology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, People's Republic of China.
Xuelin FengDepartment of Neurology, the First Affiliated Hospital, Sun Yat-sen University, No 58, Zhongshan 2 Road, Guangzhou, 510080, Guangdong Province, People's Republic of China.
Weixi ZhangDepartment of Neurology, the First Affiliated Hospital, Sun Yat-sen University, No 58, Zhongshan 2 Road, Guangzhou, 510080, Guangdong Province, People's Republic of China. zhangwxi@mail.sysu.edu.cn.
Sun Yat-sen University · CNGuangzhou Medical University · CNPeking University Shenzhen Hospital · CNThe First Affiliated Hospital, Sun Yat-sen University · CNThird Affiliated Hospital of Sun Yat-sen University · CN

Funding

National Natural Science Foundation of China 81701240Natural Science Foundation of Guangdong Province 2016A030310283Natural Science Foundation of Guangdong Province 2017A030313850
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is an X-linked genetic neuromuscular disease that is characterized by progressive muscle wasting and by defects in the regenerative capacity and inflammatory infiltration of muscle. Many noncoding RNAs (ncRNAs) participate in the pathophysiological mechanisms of this disease. To explore the role of circular RNAs (circRNAs), a type of ncRNAs, in DMD, microarray analysis was performed to explore the expression patterns of circRNAs in the gastrocnemius muscles in mdx mice, a DMD animal model, and C57 mice. The microarray data were validated by qRT-PCR. Further, gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed to predict the function of the differentially expressed circRNAs (DEcRNAs). A circRNA/microRNA (miRNA) interaction network was predicted by bioinformatics. We also predicted the protein-coding ability of the circRNAs based on their N

Indexed as

Open Reading FramesAnimalsGene Regulatory NetworksMiceMice, Inbred C57BLMice, Inbred mdxMicroRNAsMuscle, SkeletalMuscular Dystrophy, DuchenneRNA, CircularTranscriptomeMicroRNAsRNA, CircularceRNACircular RNAs (circRNAs)Duchenne muscular dystrophyExpression profileMuscleProtein-coding ability

Identifiers

PMID31736012
OpenAlexW2985670377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.