ArticleJournal of epidemiology2020
Relationships Between Reproductive History and Mortality From Cardiovascular Diseases Among Japanese Women: The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) Study.
Article in Journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Association of grand multiparity with adverse birth outcomes and sociodemographic characteristics: an analysis of nationwide birth data in Japan.Reproductive health · 2025Article
- Association between parities and duration of breastfeeding and the severity of coronary artery disease in women above 30 years old age (A pilot study).Caspian journal of internal medicine · 2024Article
- Number of Children and Risk of Cardiovascular Disease in Japanese Women: Findings from the Tohoku Medical Megabank.Journal of atherosclerosis and thrombosis · 2023Article
- The association of reproductive history with hypertension and obesity according to menopausal status: the J-MICC Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Fertility Histories and Heart Disease in Later Life in China.Frontiers in public health · 2022Article
- Management of Ischemic Heart Disease in Pregnancy.Current atherosclerosis reports · 2021Review
- Plasma Inorganic Pyrophosphate Deficiency Links Multiparity to Cardiovascular Disease Risk.Frontiers in cell and developmental biology · 2020Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReproductive history has been addressed as a risk factor for cardiovascular disease (CVD). We examined the relationship between reproductive history and CVD mortality in Japanese women.
methodsWe followed 53,836 women without previous CVD or cancer history from 1988-1990 to 2009 in a prospective cohort study. Hazard ratios (HRs) and 95% confidence intervals (CIs) of CVD mortality were estimated according to the number of deliveries and maternal age at first delivery.
resultsDuring the follow-up, 2,982 CVD-related deaths were identified. There was U-shaped association between the number of deliveries and risk of CVD mortality with reference to three deliveries, although the excess risk of CVD mortality associated with ≥5 deliveries was of borderline statistical significance. The corresponding multivariable HRs were 1.33 (95% CI, 1.12-1.58) and 1.11 (95% CI, 0.99-1.24). In addition, higher CVD mortality was associated with maternal age ≥28 years at first delivery than maternal age of 24-27 years at first delivery. The multivariable HRs were 1.22 (95% CI, 1.10-1.36) for 28-31 years at first delivery and 1.26 (95% CI, 1.04-1.52) for ≥32 years at first delivery. Moreover, among women with ≥3 deliveries, maternal age ≥28 years at first delivery was associated with 1.2- to 1.5-fold increased CVD mortality.
conclusionThe number of deliveries showed a U-shaped association with risk of CVD mortality. Higher maternal age at first delivery was associated with an increased risk of CVD mortality, and excessive risk in women aged ≥28 years at first delivery was noted in those with ≥3 deliveries.
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