Evidence map›Paper›PMID 31735730›Full record

ArticleThe Journal of veterinary medical science2020

DNase γ-dependent DNA fragmentation causes karyolysis in necrotic hepatocyte.

Shuhei Takada, Taiki Watanabe, Ryushin Mizuta

Open access · diamondAbstract read
In one paragraph

Article in The Journal of veterinary medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Nanoparticle Transport in Proximal Tubules with Rhabdomyolysis-Induced Necrosis.Angewandte Chemie (International ed. in English) · 2025
    Article
  4. Article
  5. Combination therapy of insulin-like growth factor I and BTP-2 markedly improves lipopolysaccharide-induced liver injury in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Shuhei TakadaResearch Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba 278-0022, Japan.
Taiki WatanabeResearch Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba 278-0022, Japan.
Ryushin MizutaResearch Institute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba 278-0022, Japan.
Tokyo University of Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Karyolysis is the complete dissolution of nuclear components of a dying cell. However, the generation mechanism has not been clarified. We studied a necrotic DNA fragmentation factor DNase γ (also known as DNase1L3) and previously found that karyolysis was inhibited in DNase γ deficient (DNase γ

Indexed as

Cell DeathDNA FragmentationAcetaminophenAnimalsChemical and Drug Induced Liver InjuryEndodeoxyribonucleasesHepatocytesKupffer CellsLiverMiceMice, KnockoutAcetaminophenDnase1l3 protein, mouseEndodeoxyribonucleasesDNA fragmentationDNase1L3DNase γkaryolysisKupffer cell

Identifiers

PMID31735730
PMCPMC6983664
OpenAlexW2986665990

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.