ArticleCurrent biology : CB2019
Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 61 citations in OpenAlex.
- Uracil-driven ROS signaling and larval TrpA1-B neuron activation are required for priming the adult Drosophila gustatory response to bacteria.PLoS biology · 2026Article
- Gustatory function of Aedes aegypti opsins and TRPA1 in avoiding a natural insect repellent.Current biology : CB · 2026Article
- Ether phospholipids modulate somatosensory responses by tuning multiple receptor functions iniScience · 2026Article
- Understanding animal temperature sensation: from molecular thermosensors to physiological impacts.Science China. Life sciences · 2026Review
- Involvement of Multiple Ion Channels and Receptors in Mediating the Insecticidal and Repellent Actions of Limonene.International journal of molecular sciences · 2025Article
- Neurexin regulates mechanical nociceptive sensitization by central inhibition inScience advances · 2025Article
- Hot breath, quick exit: aphids flee mammalian heat via TRPA1.Science China. Life sciences · 2025Article
- Bichromatic Exon-Reporters Reveal Voltage-Gated CaeNeuro · 2025Article
- Exploiting TRP channel diversity in insects: a pathway to next-generation pest management.Archives of toxicology · 2025Review
- Control of odor sensation by light and cryptochrome in theiScience · 2025Article
- Alternative Splicing in TRPA1 Drives Sensory Adaptation to Electrophiles in Drosophilids.bioRxiv : the preprint server for biology · 2025Article
- Thermosensory Roles of G Protein-Coupled Receptors and Other Cellular Factors in Animals.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Multiple mechanisms of action for an extremely painful venom.Current biology : CB · 2025Article
- A nociceptor-specific RNAi screen inPeerJ · 2025Article
- Article
- Multiple mechanisms of action of an extremely painful venom.bioRxiv : the preprint server for biology · 2024Article
- Article
- Functional relationship between peripheral thermosensation and behavioral thermoregulation.Frontiers in neural circuits · 2024Review
- Coordination of Pickpocket ion channel delivery and dendrite growth in Drosophila sensory neurons.PLoS genetics · 2023Article
- Alleviation of thermal nociception depends on heat-sensitive neurons and a TRP channel in the brain.Current biology : CB · 2023Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Transcripts of noxious stimulus-detecting TrpA1 channels are alternatively spliced. Despite the importance of nociception for survival, the in vivo significance of expressing different TrpA1 isoforms is largely unknown. Here, we develop a novel genetic approach to generate Drosophila knockin strains expressing single TrpA1 isoforms. Drosophila TrpA1 mediates heat and UVC-triggered nociception. We show that TrpA1-C and TrpA1-D, two alternative isoforms, are co-expressed in nociceptors. When examined in heterologous cells, both TrpA1-C and TrpA1-D are activated by heat and UVC. By contrast, analysis of knockin flies reveals the striking functional specificity; TrpA1-C mediates UVC-nociception, whereas TrpA1-D mediates heat-nociception. Therefore, in vivo functions of TrpA1-C and TrpA1-D are different from each other and are different from their in vitro properties. Our results indicate that a given sensory stimulus preferentially activates a single TrpA1 isoform in vivo and that polymodal nociception requires co-expression of TrpA1 isoforms, providing novel insights of how alternative splicing regulates nociception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.