ArticleDevelopmental cell2019
Parallel Processing of Two Mechanosensory Modalities by a Single Neuron in C. elegans.
Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 85 citations in OpenAlex.
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- Evolution of sensory systems underlies the emergence of predatory feeding behaviours in nematodes.bioRxiv : the preprint server for biology · 2025Article
- Analysis and Quantification of Functional Regeneration of Dendrite and Axon of PVD Neuron After Laser Injury inBio-protocol · 2025Article
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- The kinetochore protein KNL-1 regulates the actin cytoskeleton to control dendrite branching.The Journal of cell biology · 2025Article
- Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins.eLife · 2025Article
- Structure-function relationships across scales: implications for atlases.Frontiers in neuroscience · 2025Article
- Endocytosis restricts dendrite branching via removing ectopically localized branching ligands.Nature communications · 2024Article
- Neuropeptide signaling network of Caenorhabditis elegans: from structure to behavior.Genetics · 2024Review
- Neuronal Injury Model Divulges Differences in Dendrite and Axonal Function and Regeneration in Adults.eNeuro · 2024Article
- Dendrite morphogenesis in Caenorhabditis elegans.Genetics · 2024Review
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- Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans.Molecular and cellular endocrinology · 2024Article
- High-Dose Ionizing Radiation Impairs Healthy Dendrite Growth inAdvances in radiation oncology · 2024Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Neurons convert synaptic or sensory inputs into cellular outputs. It is not well understood how a single neuron senses, processes multiple stimuli, and generates distinct neuronal outcomes. Here, we describe the mechanism by which the C. elegans PVD neurons sense two mechanical stimuli: external touch and proprioceptive body movement. These two stimuli are detected by distinct mechanosensitive DEG/ENaC/ASIC channels, which trigger distinct cellular outputs linked to mechanonociception and proprioception. Mechanonociception depends on DEGT-1 and activates PVD's downstream command interneurons through its axon, while proprioception depends on DEL-1, UNC-8, and MEC-10 to induce local dendritic Ca
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