ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2020
Histopathological growth patterns and positive margins after resection of colorectal liver metastases.
Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Prognostic value of desmoplastic growth patterns in resected hepatocellular carcinoma.Scientific reports · 2026Article
- Encapsulated histopathological growth pattern of colorectal liver metastases predicts prolonged survival after repeat liver resection for recurrence.Clinical & experimental metastasis · 2026Article
- The Effect of Hepatic Surgical Margins of Colorectal Liver Metastases on Prognosis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Review
- Microscopic Growth Pattern of Metastatic Colorectal Carcinomas, Morphological Findings of the Non-Neoplastic Liver, and Their Relationship With Prognosis and Survival.International journal of surgical pathology · 2024Article
- Histopathological Growth Patterns Determine the Outcomes of Colorectal Cancer Liver Metastasis Following Liver Resection.Cancers · 2024Article
- A narrative review of intraoperative use of indocyanine green fluorescence imaging in gastrointestinal cancer: situation and future directions.Journal of gastrointestinal oncology · 2023Review
- Histopathological growth pattern of liver metastases as an independent marker of metastatic behavior in different primary cancers.Frontiers in oncology · 2023Article
- The Histopathological Growth Pattern of Colorectal Liver Metastases Impacts Local Recurrence Risk and the Adequate Width of the Surgical Margin.Annals of surgical oncology · 2022Article
- Clinical implications and mechanism of histopathological growth pattern in colorectal cancer liver metastases.World journal of gastroenterology · 2022Review
- Predicting 10-year survival after resection of colorectal liver metastases; an international study including biomarkers and perioperative treatment.European journal of cancer (Oxford, England : 1990) · 2022Article
- Delineating the molecular landscape of different histopathological growth patterns in colorectal cancer liver metastases.Frontiers in immunology · 2022Article
- Contemporary evidence on colorectal liver metastases ablation: toward a paradigm shift in locoregional treatment.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2022Article
- Infiltrative Tumor Borders in Colorectal Liver Metastasis: Should We Enlarge Margin Size?Annals of surgical oncology · 2021Article
- Laparoscopic liver resection for colorectal liver metastases - short- and long-term outcomes: A systematic review.World journal of gastrointestinal oncology · 2021Article
- Histopathological Growth Patterns and Survival After Resection of Colorectal Liver Metastasis: An External Validation Study.JNCI cancer spectrum · 2021Article
- Simultaneous colorectal and parenchymal-sparing liver resection for advanced colorectal carcinoma with synchronous liver metastases: Between conventional and mini-invasive approaches.World journal of gastroenterology · 2020Review
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundHistopathological growth patterns (HGPs) of colorectal liver metastases (CRLM) may be an expression of biological tumour behaviour impacting the risk of positive resection margins. The current study aimed to investigate whether the non-desmoplastic growth pattern (non-dHGP) is associated with a higher risk of positive resection margins after resection of CRLM.
methodsAll patients treated surgically for CRLM between January 2000 and March 2015 at the Erasmus MC Cancer Institute and between January 2000 and December 2012 at the Memorial Sloan Kettering Cancer Center were considered for inclusion.
resultsOf all patients (n = 1302) included for analysis, 13% (n = 170) had positive resection margins. Factors independently associated with positive resection margins were the non-dHGP (odds ratio (OR): 1.79, 95% confidence interval (CI): 1.11-2.87, p = 0.016) and a greater number of CRLM (OR: 1.15, 95% CI: 1.08-1.23 p < 0.001). Both positive resection margins (HR: 1.41, 95% CI: 1.13-1.76, p = 0.002) and non-dHGP (HR: 1.57, 95% CI: 1.26-1.95, p < 0.001) were independently associated with worse overall survival.
conclusionPatients with non-dHGP are at higher risk of positive resection margins. Despite this association, both positive resection margins and non-dHGP are independent prognostic indicators of worse overall survival.
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