Evidence map›Paper›PMID 31735512›Full record

ArticleTrends in immunology2019

Kupffer Cells Mediate Systemic Antifungal Immunity.

Carolina Coelho, Rebecca A Drummond

Abstract readComment
In one paragraph

Article in Trends in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Fungal Infections in Disorders of Inborn Errors of Immunity.Clinical reviews in allergy & immunology · 2026
    Review
  2. Article
  3. Review
  4. Anti-Inflammatory Effect ofPharmaceuticals (Basel, Switzerland) · 2023
    Article
  5. Review
  6. Article
  7. Mechanisms of fungal dissemination.Cellular and molecular life sciences : CMLS · 2021
    Review
  8. Article
  9. Mechanisms of PathogenicFrontiers in cellular and infection microbiology · 2020
    Review
  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Carolina CoelhoMedical Research Council Centre for Medical Mycology, Department of Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, UK. Electronic address: c.coelho@exeter.ac.uk.
Rebecca A DrummondInstitute of Immunology and Immunotherapy, Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK. Electronic address: r.drummond@bham.ac.uk.

Funding

Medical Research Council MR/N006364/1Medical Research Council MR/S024611/1
6 · The paper itself

Abstract

Patients with liver dysfunction have increased susceptibility to fungal infections. A recently published article (Sun et al.) describes the potential mechanism underlying this association, which maps to the antifungal activity of liver-resident Kupffer cells. This research highlights the importance of understanding tissue-specific immune responses in disease pathogenesis.

Indexed as

Kupffer CellsLiver DiseasesAntifungal AgentsHumansImmunityLiverAntifungal Agents

Identifiers

PMID31735512
PMCPMC7960509

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.