Evidence map›Paper›PMID 31735496›Full record

ArticleCell2019

Periodic Remodeling in a Neural Circuit Governs Timing of Female Sexual Behavior.

Sayaka Inoue, Renzhi Yang, Adarsh Tantry, Chung-Ha Davis, Taehong Yang, Joseph R Knoedler, Yichao Wei, Eliza L Adams, Shivani Thombare, Samantha R Golf and 4 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 135 citations in OpenAlex.

  1. Neural circuits for mammalian parental behaviour.Nature reviews. Neuroscience · 2026
    Review
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  10. Context rescales a social action code in a hormone-sensitive network.bioRxiv : the preprint server for biology · 2025
    Article
  11. Review
  12. Estrogen Control of Social Behaviors.Annual review of neuroscience · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Sayaka InoueDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Renzhi YangBiology Program, Stanford University, Stanford, CA 94305, USA.
Adarsh TantryDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Chung-Ha DavisNeurosciences Program, Stanford University, Stanford, CA 94305, USA.
Taehong YangDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Joseph R KnoedlerDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Yichao WeiDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Eliza L AdamsNeurosciences Program, Stanford University, Stanford, CA 94305, USA.
Shivani ThombareDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
Samantha R GolfNeurosciences Program, Stanford University, Stanford, CA 94305, USA.
Rachael L NeveGene Delivery Technology Core, Massachusetts General Hospital, Cambridge, MA 02139, USA.
Marc Tessier-LavigneDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Jun B DingDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA; Department of Neurology, Stanford University, Stanford, CA 94305, USA.
Nirao M ShahDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Department of Neurobiology, Stanford University, Stanford, CA 94305, USA. Electronic address: nirao@stanford.edu.
Stanford University · USMassachusetts General Hospital · USStanford Medicine · US

Funding

Characterization of Sexual Dimorphism in the BrainR01NS049488 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nirao Mahesh Shah · 2005 to 2026
$8.7M
Dopamine modulation of synaptic plasticity and integration in the striatumR01NS091144 · NINDS · STANFORD UNIVERSITY · PI Jun Ding · 2015 to 2026
$4.2M
Dissecting hypothalamic pathways that regulate sexually dimorphic behaviorsR01NS083872 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHAH, NIRAO MAHESH · 2013 to 2017
$1.8M
NINDS NIH HHS R01 NS049488NINDS NIH HHS R01 NS083872NINDS NIH HHS R01 NS091144
6 · The paper itself

Abstract

Behaviors are inextricably linked to internal state. We have identified a neural mechanism that links female sexual behavior with the estrus, the ovulatory phase of the estrous cycle. We find that progesterone-receptor (PR)-expressing neurons in the ventromedial hypothalamus (VMH) are active and required during this behavior. Activating these neurons, however, does not elicit sexual behavior in non-estrus females. We show that projections of PR+ VMH neurons to the anteroventral periventricular (AVPV) nucleus change across the 5-day mouse estrous cycle, with ∼3-fold more termini and functional connections during estrus. This cyclic increase in connectivity is found in adult females, but not males, and regulated by estrogen signaling in PR+ VMH neurons. We further show that these connections are essential for sexual behavior in receptive females. Thus, estrogen-regulated structural plasticity of behaviorally salient connections in the adult female brain links sexual behavior to the estrus phase of the estrous cycle.

Indexed as

AnimalsEstrogensEstrous CycleFemaleGonadal Steroid HormonesHypothalamus, AnteriorMaleMice, Inbred C57BLNerve NetNeuronal PlasticityNeuronsOvaryPresynaptic TerminalsReceptors, ProgesteroneSexual Behavior, AnimalSignal TransductionEstrogensGonadal Steroid HormonesReceptors, Progesteroneanteroventral periventricular nucleusemotional behaviorestrogen, progesteroneestrous cycleplasticitysexual behaviorsexually dimorphic behaviorventromedial hypothalamus

Identifiers

PMID31735496
PMCPMC7096331
OpenAlexW2989148135

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.