Evidence map›Paper›PMID 31735169›Full record

ArticleMolecular cancer2019

YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma.

Jiajie Hou, He Zhang, Jun Liu, Zhenjun Zhao, Jianye Wang, Zhike Lu, Bian Hu, Jiankui Zhou, Zhicong Zhao, Mingxuan Feng and 7 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 229 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
229citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

229 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. RNA methylation in vascular disease: a systematic review.Journal of cardiothoracic surgery · 2022
    Pooled it
  2. Review
  3. Hypoxia-induced mGenes & diseases · 2026
    Article
  4. Article
  5. Article
  6. ALKBH5 aggravates scarring after glaucoma surgery via mCell death and differentiation · 2026
    Article
  7. Article
  8. Review
  9. Beyond transcription: RNA-binding proteins steering angiogenesis.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  10. mFrontiers in cell and developmental biology · 2026
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. mActa pharmaceutica Sinica. B · 2025
    Review
  18. Article
  19. Review
  20. Article

169 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Jiajie HouDepartment of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China. houjj@sysucc.org.cn.
He ZhangDepartment of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Jun LiuDepartment of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, 60637, USA.
Zhenjun ZhaoDepartment of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Jianye WangDepartment of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Zhike LuDepartment of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, 60637, USA.
Bian HuSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Jiankui ZhouSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Zhicong ZhaoDepartment of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Mingxuan FengDepartment of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Haiyan ZhangState Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Bin ShenKey Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, 211166, China.
Xingxu HuangSchool of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Beicheng SunDepartment of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210093, China.
Mark J Smyth
Chuan HeDepartment of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, University of Chicago, Chicago, IL, 60637, USA. chuanhe@uchicago.edu.
Qiang XiaDepartment of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China. xiaqiang@shsmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDynamic N

resultsUsing liquid chromatography-tandem mass spectrometry and m

conclusionOur results have characterized the m

Indexed as

AdenosineAnimalsCarcinoma, HepatocellularEpigenesis, GeneticHumansInflammationLiver NeoplasmsMethylationMiceModels, BiologicalNeovascularization, PathologicRNA-Binding ProteinsRNA, MessengerTranscriptomeAdenosineN-methyladenosineRNA-Binding ProteinsRNA, MessengerYTHDF2 protein, humanHCCHIF-2α antagonismIL-11Inflammationm6ASerpin E2Vessel normalizationYTHDF2

Identifiers

PMID31735169
PMCPMC6859620

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.