Evidence map›Paper›PMID 31735124›Full record

ReviewNanomedicine (London, England)2019

miRNAs in gastrointestinal diseases: can we effectively deliver RNA-based therapeutics orally?

A K M Nawshad Hossian, Gerardo G Mackenzie, George Mattheolabakis

Open access · greenAbstract readReview
In one paragraph

Review in Nanomedicine (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. The Conundrum of XenomiRs and Human Health.Advances in nutrition (Bethesda, Md.) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

A K M Nawshad HossianSchool of Basic Pharmaceutical & Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.ORCID 0000-0003-1792-4528
Gerardo G MackenzieDepartment of Nutrition, University of California, Berkeley, CA 95616, USA.
George MattheolabakisSchool of Basic Pharmaceutical & Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.ORCID 0000-0002-6246-8421
University of Louisiana at Monroe · USUniversity of California, Berkeley · US

Funding

STABILITY' (symptomatic review during biologic therapy) Review in Inflammatory Bowel DiseaseP20GM103424 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI Seetharama D Jois · 2012 to 2026
$57.4M
Reprogramming Tumor-Associated Macrophages in PDAC with MicroRNA Nano-VectorsR21CA213114 · NCI · NORTHEASTERN UNIVERSITY · PI AMIJI, MANSOOR M., MACKENZIE, GERARDO GUILLERMO · 2017 to 2018
$388k
NCI NIH HHS R21 CA213114NIGMS NIH HHS P20 GM103424
6 · The paper itself

Abstract

Nucleic acid-based therapeutics are evaluated for their potential of treating a plethora of diseases, including cancer and inflammation. Short nucleic acids, such as miRNAs, have emerged as versatile regulators for gene expression and are studied for therapeutic purposes. However, their inherent instability

Indexed as

Administration, OralAnimalsBiological TransportGastrointestinal DiseasesGastrointestinal TractGene Expression RegulationGenetic TherapyGene Transfer TechniquesHumansLipidsMicroRNAsNanocapsulesPolymersRNA, Small InterferingSurface PropertiesLipidsMicroRNAsNanocapsulesPolymersRNA, Small InterferingdeliverymiRNA therapeuticsnon-viral vectorsoral delivery

Identifiers

PMID31735124
PMCPMC7026766
OpenAlexW2987929276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.