Evidence map›Paper›PMID 31735119›Full record

ArticleCell cycle (Georgetown, Tex.)2019

Fibroblast growth factor 9 (FGF9) inhibits myogenic differentiation of C2C12 and human muscle cells.

Jian Huang, Kun Wang, Lora A Shiflett, Leticia Brotto, Lynda F Bonewald, Michael J Wacker, Sarah L Dallas, Marco Brotto

Open access · bronzeAbstract read
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

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  6. A Functional Regulatory Variant ofAnimals : an open access journal from MDPI · 2025
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  11. Hyperphosphatemia Contributes to Skeletal Muscle Atrophy in Mice.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jian HuangBone-Muscle Research Center, College of Nursing & Health Innovation, the University of Texas at Arlington, Arlington, TX, USA.
Kun WangDepartment of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO, USA.
Lora A ShiflettDepartment of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO, USA.
Leticia BrottoBone-Muscle Research Center, College of Nursing & Health Innovation, the University of Texas at Arlington, Arlington, TX, USA.
Lynda F BonewaldIndiana Center for Musculoskeletal Health, School of Medicine, Indiana University, Indianapolis, IN USA.
Michael J WackerDepartment of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA.
Sarah L DallasDepartment of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO, USA.ORCID https://orcid.org/0000-0002-5197-891X
Marco BrottoBone-Muscle Research Center, College of Nursing & Health Innovation, the University of Texas at Arlington, Arlington, TX, USA.
University of Missouri–Kansas City · USThe University of Texas at Arlington · USIndiana University – Purdue University Indianapolis · US

Funding

Transgenic and Mechanical Loading CoreP01AG039355 · NIA · UNIVERSITY OF MISSOURI KANSAS CITY · PI BONEWALD, LYNDA F · 2012 to 2024
$19.3M
Regulation of Store-Operated Calcium Entry During Muscle AgingR01AG056504 · NIA · OHIO STATE UNIVERSITY · PI BROTTO, MARCO, WEISLEDER, NOAH · 2018 to 2022
$2.6M
Loss of Numb in Muscle Dysfunction in AgingR01AG060341 · NIA · BRONX VETERANS MEDICAL RESEARCH FDN · PI BROTTO, MARCO, CARDOZO, CHRISTOPHER P · 2018 to 2022
$2.4M
NIA NIH HHS P01 AG039355NIA NIH HHS R01 AG056504NIA NIH HHS R01 AG060341
6 · The paper itself

Abstract

Osteoporosis and sarcopenia (osteosarcopenia (OS)) are twin-aging diseases. The biochemical crosstalk between muscle and bone seems to play a role in OS. We have previously shown that osteocytes produce soluble factors with beneficial effects on muscle and

Indexed as

AnimalsCaffeineCalciumCell LineCell ProliferationCells, CulturedFibroblast Growth Factor 9Fibroblast Growth FactorsGene Expression RegulationHumansMaleMiceMice, Inbred C57BLMuscle DevelopmentMuscle Fibers, SkeletalOrganelle BiogenesisCaffeineCalciumFibroblast Growth Factor 9Fibroblast Growth FactorsC2C12 myoblastdifferentiationFGF9human skeletal muscle cellsproliferation

Identifiers

PMID31735119
PMCPMC6927711
OpenAlexW2983461306

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.