Evidence map›Paper›PMID 31734880›Full record

ArticleMolecular neurobiology2020

Alterations of Transcription of Genes Coding Anti-oxidative and Mitochondria-Related Proteins in Amyloid β Toxicity: Relevance to Alzheimer's Disease.

Magdalena Cieślik, Grzegorz A Czapski, Sylwia Wójtowicz, Iga Wieczorek, Przemysław L Wencel, Robert P Strosznajder, Vivian Jaber, Walter J Lukiw, Joanna B Strosznajder

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  14. Mitochondria transcription and cancer.Cell death discovery · 2024
    Review
  15. Roles of MT-ND1 in Cancer.Current medical science · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Magdalena CieślikDepartment of Cellular Signaling, Mossakowski Medical Research Centre Polish Academy of Sciences, Pawińskiego 5, 02-106, Warsaw, Poland.
Grzegorz A CzapskiDepartment of Cellular Signaling, Mossakowski Medical Research Centre Polish Academy of Sciences, Pawińskiego 5, 02-106, Warsaw, Poland.
Sylwia WójtowiczDepartment of Cellular Signaling, Mossakowski Medical Research Centre Polish Academy of Sciences, Pawińskiego 5, 02-106, Warsaw, Poland.
Iga WieczorekLaboratory of Preclinical Research and Environmental Agents, Mossakowski Medical Research Centre Polish Academy of Sciences, Pawińskiego 5, 02-106, Warsaw, Poland.
Przemysław L WencelLaboratory of Preclinical Research and Environmental Agents, Mossakowski Medical Research Centre Polish Academy of Sciences, Pawińskiego 5, 02-106, Warsaw, Poland.
Robert P StrosznajderLaboratory of Preclinical Research and Environmental Agents, Mossakowski Medical Research Centre Polish Academy of Sciences, Pawińskiego 5, 02-106, Warsaw, Poland.
Vivian JaberLSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.
Walter J LukiwLSU Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.
Joanna B StrosznajderDepartment of Cellular Signaling, Mossakowski Medical Research Centre Polish Academy of Sciences, Pawińskiego 5, 02-106, Warsaw, Poland. jstrosznajder@imdik.pan.pl.ORCID http://orcid.org/0000-0002-6213-1212
Mossakowski Medical Research Institute, Polish Academy of Sciences · PLLouisiana State University Health Sciences Center New Orleans · US

Funding

OCULAR HSV: LATENCY, REACTIVATION, &RECURRENCER01EY006311 · NEI · LSU HEALTH SCIENCES CENTER · PI HILL, JAMES M · 1985 to 2012
$5.3M
microRNA (miRNA) signaling in Alzheimer's disease(AD)R01AG038834 · NIA · LSU HEALTH SCIENCES CENTER · PI BAZAN, NICOLAS G. · 2011 to 2020
$3.3M
Gene Expression in Alzheimer's DiseaseR01AG018031 · NIA · LSU HEALTH SCIENCES CENTER · PI LUKIW, WALTER J · 2001 to 2006
$1.4M
NEI NIH HHS R01 EY006311NIA NIH HHS R01 AG018031NIA NIH HHS R01 AG038834NIH HHS NEI EY006311NIH HHS NIA AG038834NIH HHS NIA AG18031
6 · The paper itself

Abstract

A growing body of evidence indicates that pathological forms of amyloid beta (Aβ) peptide contribute to neuronal degeneration and synaptic loss in Alzheimer's disease (AD). In this study, we investigated the impact of exogenous Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsHumansMiceMicrogliaMicroRNAsMitochondriaMitochondrial ProteinsNeuronsOxidative StressAmyloid beta-PeptidesMicroRNAsMitochondrial ProteinsAlzheimer’s diseaseAmyloid betaGene expressionMicroglial cellsmiRNA-146aNeuronal cells

Identifiers

PMID31734880
PMCPMC7061023
OpenAlexW2985596633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.