Evidence map›Paper›PMID 31734862›Full record

ArticleParasitology research2020

Prevention of transmission of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum by Ixodes spp. ticks to dogs treated with the Seresto® collar (imidacloprid 10% + flumethrin 4.5%).

Friederike Krämer, Ricarda Hüsken, Eva Maria Krüdewagen, Katrin Deuster, Byron Blagburn, Reinhard K Straubinger, Jamie Butler, Volker Fingerle, Sam Charles, Terry Settje and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Parasitology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Knowledge mapping of risk mitigation measures against vector-borne diseases.EFSA journal. European Food Safety Authority · 2026
    Article
  2. Review
  3. First molecular evidence ofOpen veterinary journal · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Friederike KrämerInstitute of Parasitology, Faculty of Veterinary Medicine, Leipzig University, 04103, Leipzig, Germany.
Ricarda HüskenBayer Animal Health GmbH, 51373, Leverkusen, Germany.
Eva Maria KrüdewagenBayer Animal Health GmbH, 51373, Leverkusen, Germany.
Katrin DeusterBayer Animal Health GmbH, 51373, Leverkusen, Germany.
Byron BlagburnDepartment of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, 36849-5519, USA.
Reinhard K StraubingerBacteriology and Mycology, Institute for Infectious Diseases and Zoonoses, Department of Veterinary Sciences, LMU Munich, 80539, Munich, Germany.
Jamie ButlerDepartment of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, 36849-5519, USA.
Volker FingerleNational Reference Centre for Borrelia, Section Infectiology, Bavarian Health and Food Safety Authority (LGL), 85764, Oberschleißheim, Germany.
Sam CharlesBayer Animal Health, Shawnee, KS, 66216, USA.
Terry SettjeBayer Animal Health, Shawnee, KS, 66216, USA.
Bettina SchunackBayer Animal Health GmbH, 51373, Leverkusen, Germany.
Dorothee StanneckBayer Animal Health GmbH, 51373, Leverkusen, Germany. dorothee.stanneck@bayer.com.ORCID http://orcid.org/0000-0002-3960-3656
Bayer (Germany) · DEAuburn University · USBayer (United States) · USBavarian State Collection of Zoology · DEMunich Security Conference · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The capability of imidacloprid 10% + flumethrin 4.5% (Seresto®) collars to prevent transmission of Borrelia burgdorferi sensu lato (Bbsl) and Anaplasma phagocytophilum (Ap) by naturally infected ticks was evaluated in two studies with 44 dogs. In each study, one group served as non-treated control, whereas the other groups were treated with the Seresto® collar. All dogs were exposed to naturally Bbsl- and Ap-infected hard ticks (Ixodes ricinus, Ixodes scapularis). In study 1, tick infestation was performed on study day (SD) 63 (2 months post-treatment [p.t.]); in study 2, it was performed on SD 32 (one month p.t.) respectively SD 219 (seven months p.t.). In situ tick counts were performed 2 days after infestation. Tick counts and removals followed 6 (study 1) or 5 days (study 2) later. Blood sampling was performed for the detection of specific Bbsl and Ap antibodies and, in study 1, for the documentation of Ap DNA by PCR. Skin biopsies were examined for Bbsl by PCR and culture (only study 1). The efficacy against Ixodes spp. was 100% at all time points. In study 1, two of six non-treated dogs became infected with Bbsl, and four of six tested positive for Ap; none of the treated dogs tested positive for Bbsl or Ap. In study 2, ten of ten non-treated dogs became infected with Bbsl and Ap; none of the treated dogs tested positive for Bbsl or Ap; 100% acaricidal efficacy was shown in both studies. Transmission of Bbsl and Ap was successfully blocked for up to 7 months.

Indexed as

AcaricidesAnaplasma phagocytophilumAnimalsAntibodies, BacterialArachnid VectorsBorrelia burgdorferiDisease Transmission, InfectiousDNA, BacterialDog DiseasesDogsEhrlichiosisIxodesLyme DiseaseNeonicotinoidsNitro CompoundsPyrethrinsAcaricidesAntibodies, BacterialDNA, BacterialflumethrinimidaclopridNeonicotinoidsNitro CompoundsPyrethrinsCanine granulocytic anaplasmosis (CGA)Canine vector-borne disease (CVBD)Lyme borreliosisPathogen blockingTransmission

Identifiers

PMID31734862
PMCPMC6942034
OpenAlexW2988578065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.