ReviewCurrent psychiatry reports2019
Opioid Use in Pregnancy.
Review in Current psychiatry reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 67 citations in OpenAlex.
- Design, implementation, and evaluation of neonatal abstinence syndrome care management web application: a multimethod study.Scientific reports · 2026Trial
- Disparities in Healthcare Providers' Substance Use Detection Practices for Pregnant Patients.Journal of racial and ethnic health disparities · 2026Article
- Maternal opioid use and hepatitis C infection disrupt the placental immune landscape and structure.JCI insight · 2026Article
- Identifying Sex Differences in Adverse Events Reported on Opioid Drugs in the FDA's Adverse Event Reporting System (FAERS).Pharmaceuticals (Basel, Switzerland) · 2026Article
- Gynecologic and Reproductive Health in Patients with Sickle Cell Disease: Underrecognized Challenges and Care Management Opportunities.Journal of clinical medicine · 2026Review
- Postpartum retention in opioid agonist treatment for opioid dependence: A population-based cohort study.Archives of women's mental health · 2026Article
- Animal Models of Prenatal Opioid Exposure: Insights into Impaired Neurodevelopment.Advances in experimental medicine and biology · 2026Review
- Learning and Memory Performance in a Rat Model of Perigestational Opioid Exposure.bioRxiv : the preprint server for biology · 2025Article
- Maternal opioid use with and without hepatitis C infection disrupts the structure and immune landscape of the maternal-fetal interface.bioRxiv : the preprint server for biology · 2025Article
- Article
- Outpatient tapering of buprenorphine in opioid use disorder pregnancies may improve neonatal outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Rural-urban differences in substance use during pregnancy.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025Article
- Maternal, Fetal, and Neonatal Outcomes of Opioid-Dependent Mothers in Iran: A case Study of Iran.Addiction & health · 2025Article
- Knowledge of medications for opioid use disorder and associated stigma among primary care professionals.Annals of medicine · 2024Article
- Reviewing the Impact of Maternal Opioid Use Disorder on Fetal Development and Long-Term Pediatric Health Outcomes.Cureus · 2024Review
- Prescription medication use during pregnancy in the United States from 2011 to 2020: trends and safety evidence.American journal of obstetrics and gynecology · 2024Article
- The effects of prenatal exposure to opioids on early childhood development: context matters most.Expert opinion on pharmacotherapy · 2024Review
- Maternal opioid use disorder and infant mortality in Wisconsin, United States, 2010-2018.Preventive medicine · 2024Article
- Uniform cerebral organoid culture on a pillar plate by simple and reproducible spheroid transfer from an ultralow attachment well plate.Biofabrication · 2024Article
- Investigating the neurobiology of maternal opioid use disorder and prenatal opioid exposure using brain organoid technology.Frontiers in cellular neuroscience · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purpose of reviewPerinatal opioid use is a major public health problem and is associated with a number of deleterious maternal and fetal effects. We review recent evidence of perinatal outcomes and treatment of opioid use disorder (OUD) during pregnancy. RECENT
findingsOpioid exposure in pregnancy is associated with multiple obstetric and neonatal adverse outcomes, with the most common being neonatal opioid withdrawal syndrome (NOWS). Treatment with buprenorphine or methadone is associated with NOWS, but neither medication appears to have significant adverse effects on early childhood development. Buprenorphine appears to be superior to methadone in terms of incidence and severity of NOWS in exposed infants. The long-term effects of opioid exposure in utero have been inconclusive, but recent longitudinal studies point to potential differences in brain morphology that may increase vulnerability to future stressors. Maintenance therapy with methadone or buprenorphine remains the standard of care for pregnant women with OUD given its consistent superiority to placebo in terms of rates of illicit drug use and pregnancy outcomes. New non-pharmacologic management options for NOWS appear promising. Future research is needed to further evaluate the effects of opioid exposure in utero and determine the optimal delivery model for maintenance therapy.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.