ArticleClinical oral investigations2020
Ex vivo histological analysis of the thermal effects created by a 445-nm diode laser in oral soft tissue biopsy.
Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Evaluating the success rates and effectiveness of surgical and orthodontic interventions for impacted canines: a systematic review of surgical and orthodontic interventions and a case series.BMC oral health · 2025Pooled it
- Histological implications of high-power laser use in the oral soft tissue lesions: a systematic review.Lasers in medical science · 2023Pooled it
- Photobiomodulation Therapy on Orthodontic Movement: Analysis of Preliminary Studies with a New Protocol.International journal of environmental research and public health · 2020Trial
- Needle-based level II temporomandibular joint arthroscopy under local anesthesia.Oral and maxillofacial surgery · 2026Article
- The Impact of Laser Thermal Effect on Histological Evaluation of Oral Soft Tissue Biopsy: Systematic Review.Dentistry journal · 2023Review
- Analysis of the Temperature Elevation of the Dual-Wavelength Diode Laser and the Er, Cr: YSGG Laser in Oral Soft Tissue Incisions.Journal of lasers in medical sciences · 2023Article
- Ultra-Pulsed COFrontiers in bioengineering and biotechnology · 2022Article
- Thermal effect of a 445 nm diode laser on five dental implant systems: an in vitro study.Scientific reports · 2021Article
- Uncovering and Autonomous Eruption of Palatally Impacted Canines-A Case Report.Dentistry journal · 2021Article
- HistologicalInternational journal of dentistry · 2021Article
- A Single Case Report of Granular Cell Tumor of the Tongue Successfully Treated through 445 nm Diode Laser.Healthcare (Basel, Switzerland) · 2020Article
- Histological Effects of an Innovative 445 Nm Blue Laser During Oral Soft Tissue Biopsy.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to evaluate, ex vivo, the histological effects of 445-nm diode laser (Eltech K-Laser srl, Treviso, Italy), during an oral soft tissue biopsy. MATERIALS AND
methodsThirty samples from pig cadaver tongues were obtained, through five laser settings, in continuous and pulsed wave (CW and PW). Samples were divided into six groups of five pieces each. A control specimen was taken by a scalpel. All samples were examined with an optical microscope by a blinded pathologist. Thermal effects on epithelium and connective tissues were measured with LAS 4.8 software. Finally, a statistical evaluation was made using GraphPadPrism 7.0 software.
resultsAll specimens, except one, showed a damage lower than 1 mm. Readability was always optimal; there was a different thermal effect between epithelial and connective tissue and in CW and PW samples, confirmed by statistical analysis too.
conclusionsA 445-nm diode laser creates a minimum thermal effect, that has no implications in the histological evaluation of benign lesions. In suspicious lesions, a safety margin of 1 mm, compared with a scalpel, is preferable. CLINICAL RELEVANCE: A 445-nm diode laser has excellent surgical properties and can manage many arduous clinical cases, such as vascularized lesions. In the excision of suspected lesions, it is necessary to compare, case by case, clinical advantages to possible histological implications.
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