ArticleClinical and experimental medicine2020
Hepatic dysfunction secondary to Kawasaki disease: characteristics, etiology and predictive role in coronary artery abnormalities.
Article in Clinical and experimental medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 37 citations in OpenAlex.
- Beyond biochemical recovery: rethinking liver dysfunction in Kawasaki disease.Translational pediatrics · 2026Article
- Biochemical outcomes and safety profiles of compound glycyrrhizin versus magnesium isoglycyrrhizinate in Kawasaki disease: a retrospective propensity score‑matched cohort study.Translational pediatrics · 2026Article
- Gastrointestinal abnormalities as predictors of cardiovascular involvement in Kawasaki disease: a 5-year retrospective study.BMC pediatrics · 2026Article
- A nomogram for predicting Kawasaki Disease in acutely febrile children with liver injury.European journal of pediatrics · 2026Article
- Relationship between Kawasaki disease and alanine aminotransferase levels in pediatric patients.World journal of hepatology · 2025Article
- Lysophosphatidylcholine as a Novel Diagnostic Biomarker in Kawasaki Disease: Based on Immunometabolism-Related Signature.Journal of inflammation research · 2025Article
- Nutrition-Associated Biomarkers in Predicting Intravenous Immunoglobulin Resistance and Coronary Artery Lesions in Kawasaki Disease: A Systematic Review and Meta-Analysis.Food science & nutrition · 2025Review
- The predictive value of urinary albumin-to-creatinine ratio for coronary artery abnormalities in Kawasaki disease.Frontiers in pediatrics · 2025Article
- Analysis and validation of clinical subgroups of Kawasaki disease in children in China: a retrospective study.BMJ paediatrics open · 2024Article
- Diagnostic value of syndecan-1 for coronary artery lesions and correlation analysis of laboratory indicators in Kawasaki disease patients.Italian journal of pediatrics · 2024Article
- The changes of coagulation profiles in Kawasaki disease and its associations with clinical classification, intravenous immunoglobulin responsiveness and coronary artery involvement.Clinical and experimental medicine · 2024Article
- Unraveling the gut: the pivotal role of intestinal mechanisms in Kawasaki disease pathogenesis.Frontiers in immunology · 2024Review
- Predicting Kawasaki disease shock syndrome in children.Frontiers in immunology · 2024Article
- The safety and effectiveness of clopidogrel versus aspirin in Kawasaki disease with mild-to-moderate liver injury.Scientific reports · 2023Article
- Anakinra and hepatotoxicity in pediatric rheumatology: a case series.Pediatric rheumatology online journal · 2023Article
- [Clinicopathological characteristics and key therapeutic options for liver involvement with vasculitis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023Review
- A machine learning model for distinguishing Kawasaki disease from sepsis.Scientific reports · 2023Article
- Prognostic nutritional index value in the prognosis of Kawasaki disease with coronary artery lesions.Frontiers in nutrition · 2023Article
- Kawasaki Disease with Hepatobiliary Manifestations.Medicina (Kaunas, Lithuania) · 2022Article
- Clinical Manifestations and Laboratory Findings of Kawasaki Disease: Beyond the Classic Diagnostic Features.Medicina (Kaunas, Lithuania) · 2022Review
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Coronary artery abnormalities (CAAs) are prominent during the acute Kawasaki disease (KD) episode and represent the major contributors to the long-term prognosis. Several meta-analysis and published scoring systems have identified hepatic dysfunction as an independent predictor of CAA risks. The medical records of 210 KD children were reviewed. Blood samples were collected from all subjects at 24 h pre-therapy and 48 h post-therapy, respectively. Liver function test (LFT) and inflammatory mediators were detected. Multivariate logistic regression analysis was conducted to identify the reliable biomarkers predicting whether CAAs existed or not in KD patients. 90.95% of KD patients had at least 1 abnormal LFT. Hypoalbuminemia was the most prevalent type of hepatic dysfunction, followed by elevated aspartate aminotransferase, low TP, low A/G and hyperbilirubinemia, respectively. The elevated inflammatory mediators (procalcitonin and C-reactive protein) and moderate dose of aspirin played a synthetic role in hepatic dysfunction secondary to KD. However, LFT presented no significant differences between infectious and noninfectious conditions. By a multivariate analysis, a lower albumin/globulin ratio (A/G, OR 13.50, 95% CI 3.944-46.23) served as an independent predictor of CAAs and had a sensitivity of 56.25%, and a specificity of 61.11% at a cutoff value of < 1.48. In conclusion, hepatic dysfunction is a common complication during the acute KD episode, characterized by elevated serum liver enzymes, hypoalbuminemia and hyperbilirubinemia. Systemic inflammation and aspirin, rather than infectious agents, are both the major contributors of hepatic dysfunction secondary to KD. A lower A/G serves as an independent predictor of CAAs.
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