Evidence map›Paper›PMID 31734744›Full record

ArticleMikrochimica acta2019

Colorimetric and fluorometric aggregation-based heparin assay by using gold nanoclusters and gold nanoparticles.

Zhipeng Zhang, Sha Li, Pengcheng Huang, Jiayu Feng, Fang-Ying Wu

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 18 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhipeng ZhangCollege of Chemistry, Nanchang University, Nanchang, 330031, China.
Sha LiCollege of Chemistry, Nanchang University, Nanchang, 330031, China.
Pengcheng HuangCollege of Chemistry, Nanchang University, Nanchang, 330031, China. pchuang@ncu.edu.cn.
Jiayu FengCollege of Chemistry, Nanchang University, Nanchang, 330031, China.
Fang-Ying WuCollege of Chemistry, Nanchang University, Nanchang, 330031, China. fywu@ncu.edu.cn.ORCID 0000-0002-8524-7904
Nanchang University · CN

Funding

National Natural Science Foundation of China 21765014National Natural Science Foundation of China 21864018the Opening Project of Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine 2018001
6 · The paper itself

Abstract

An optical nanoprobe consisting of gold nanoclusters (AuNCs) and gold nanoparticles (AuNPs) is described for ultrasensitive detection of heparin (Hep). Polyethyleneimine (PEI) induces the aggregation of AuNPs which results in a color change from wine red (peak at 520 nm) to blue (peak at 610 nm). In parallel, the fluorescence of AuNCs (with excitation/emission maxima at 370/610 nm) is weakened. However, in the presence of Hep (which is strongly negatively charged), it will electrostatically bind to positively charged PEI and then will prevent aggregation. Hence, the color changes from blue (aggregated) to red (non-aggregated). In parallel, fluorescence remains unchanged. Hep can be quantified by using the nanoprobe in the range of 4-220 ng·mL

Indexed as

Color changeElectrostatic interactionFluorescence quenchingHuman serumInner filter effectNanoprobePolyethyleneimineSurface plasmon resonanceTransmission electron microscopy

Identifiers

PMID31734744
OpenAlexW2988383146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.