ArticleNeuroImage2020
The association between BOLD-based cerebrovascular reactivity (CVR) and end-tidal CO
Open access · hybridAbstract read
In one paragraph
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Reproducibility of cerebrovascular reactivity measurements: A systematic review of neuroimaging techniquesJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Pooled it
- Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review.Frontiers in physiology · 2021Pooled it
- A Data-Driven Normalization Framework for Subject-Specific Cerebrovascular Reactivity Assessment in Cerebrovascular Disease.Journal of magnetic resonance imaging : JMRI · 2026Article
- Editorial for "A Data-Driven Normalization Framework for Subject-Specific Cerebrovascular Reactivity Assessment in Cerebrovascular Disease".Journal of magnetic resonance imaging : JMRI · 2026Article
- Sex comparison of cerebrovascular reactivity to COJournal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Blood-oxygenation-level-dependent (BOLD) MRI responses to COMagnetic resonance imaging · 2025Article
- The influence of cardiovascular fitness and ventilatory efficiency on fMRI assessed cerebrovascular reactivity in older adults.Frontiers in physiology · 2025Article
- Alterations of cerebrovascular reactivity following pediatric mild traumatic brain injury are independent of neurodevelopmental changes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Problems and solutions in quantifying cerebrovascular reactivity using BOLD-MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Cerebrovascular reactivity mapping using breath-hold BOLD-fMRI: Comparison of signal models combined with voxelwise lag optimization.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The dependence of COImaging neuroscience (Cambridge, Mass.) · 2025Article
- Correlation of breathing task derived cerebrovascular reactivity with baseline CBF, OEF and CMROFrontiers in neurology · 2025Article
- Evaluating cerebrovascular reactivity measured by velocity selective inversion arterial spin labeling with different post-labeling delays: The effect of fast flow.Magnetic resonance in medicine · 2024Article
- Cerebrovascular reactivity MRI as a biomarker for cerebral small vessel disease-related cognitive decline: Multi-site validation in the MarkVCID Consortium.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Article
- Reduced and Delayed Cerebrovascular Reactivity in Patients with Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Deep-learning-enabled brain hemodynamic mapping using resting-state fMRI.NPJ digital medicine · 2023Article
- Sinusoidal COFrontiers in physiology · 2023Article
- Initiation of combined antiretroviral therapy confers suboptimal beneficial effects on neurovascular function in people with HIV.Frontiers in neurology · 2023Article
- Cerebrovascular reactivity measurements using 3T BOLD MRI and a fixed inhaled COFrontiers in physiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 1 country.
Xirui HouDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; The Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Peiying LiuThe Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Yang LiThe Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Dengrong JiangDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; The Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jill B De VisThe Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zixuan LinDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; The Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sandeepa SurThe Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zachary BakerDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; The Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Deng MaoF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA; Philips Healthcare, Baltimore, MD, USA.
Harshan RaviDepartment of Cancer Physiology, Moffitt Cancer Research Center, Tampa, FL, USA.
Karen RodrigueCenter for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.
Marilyn AlbertDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Denise C ParkCenter for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA.
Hanzhang LuDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA; The Russell H. Morgan Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA. Electronic address: hanzhang.lu@jhu.edu.
Johns Hopkins University · USJohns Hopkins Medicine · USKennedy Krieger Institute · USThe University of Texas at Dallas · USMoffitt Cancer Center · US
Funding
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2020 to 2026
$29.3MNeuroimaging of Dedifferentiation and Memory Across the LifespanR37AG006265 · NIA · UNIVERSITY OF TEXAS DALLAS · PI PARK, DENISE CORTIS · 2006 to 2016
$8.5MDallas Lifespan Brain Study-Wave 3: Neurodegeneration & Resilience in CognitionRF1AG006265 · NIA · UNIVERSITY OF TEXAS DALLAS · PI PARK, DENISE CORTIS · 2017 to 2019
$7.1MNormalized functional MRI in human brain disordersR01MH084021 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG · 2008 to 2017
$3.6MDevelopment of MRI microvascular biomarkers in cognitive impairment and dementiaUH3NS100588 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S., LU, HANZHANG · 2018 to 2020
$3.5MAn integrated vascular MR imaging suite in brain diseasesR01NS106702 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.7MDevelopment of MRI microvascular biomarkers in cognitive impairment and dementiaUH2NS100588 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S., LU, HANZHANG · 2016 to 2018
$2.3MMR fingerprinting (MRF) perfusion imaging in cerebral vascular diseaseR01NS106711 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2018 to 2022
$2.2MCalibration of fMRI in Emotional AgingR21AG061851 · NIA · JOHNS HOPKINS UNIVERSITY · PI LIU, PEIYING, LU, HANZHANG · 2019 to 2020
$465kNIA NIH HHS P30 AG066507NIA NIH HHS R21 AG061851NIA NIH HHS R37 AG006265NIA NIH HHS RF1 AG006265NIMH NIH HHS R01 MH084021NINDS NIH HHS R01 NS106702NINDS NIH HHS R01 NS106711NINDS NIH HHS UH2 NS100588NINDS NIH HHS UH3 NS100588
Abstract
Cerebrovascular reactivity (CVR) mapping using CO
Indexed as
AdultAgedBrainBrain MappingCarbon DioxideCerebrovascular CirculationFemaleHealthy VolunteersHumansHypercapniaMagnetic Resonance ImagingMaleMiddle AgedYoung AdultCarbon DioxideBlood-oxygenation-level-dependent (BOLD) MRICerebrovascular reactivity (CVR)End-tidal CO(2)HypercapniaVasodilation
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.