Evidence map›Paper›PMID 31734416›Full record

ArticleRespiratory physiology & neurobiology2020

Respiratory resetting elicited by single pulse spinal stimulation.

Michael D Sunshine, Comron N Ganji, David D Fuller, Chet T Moritz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. [Closed-loop regulation system for paralyzed lower limb joint movement based on electrical stimulation of spinal central pattern generator].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael D SunshineDepartment of Rehabilitation Medicine, University of Washington, United States; Center for Neurotechnology, an NSF ERC, United States; Department of Physical Therapy, University of Florida, United States; McKnight Brain Institute, University of Florida, United States; Rehabilitation Science PhD Program, University of Florida, United States; Center for Respiratory Research and Rehabilitation, University of Florida, United States. Electronic address: mdsunshi@ufl.edu.
Comron N GanjiDepartment of Rehabilitation Medicine, University of Washington, United States.
David D FullerDepartment of Physical Therapy, University of Florida, United States; McKnight Brain Institute, University of Florida, United States; Center for Respiratory Research and Rehabilitation, University of Florida, United States.
Chet T MoritzDepartment of Rehabilitation Medicine, University of Washington, United States; Center for Neurotechnology, an NSF ERC, United States; Center for Respiratory Research and Rehabilitation, University of Florida, United States; Department of Electrical and Computer Engineering, United States; University of Washington, Institute for Neuroengineering (UWIN), University of Washington, United States; Department of Physiology and Biophysics, University of Washington, United States.

Funding

Training In Rehabilitation and Neuromuscular PlasticityT32HD043730 · NICHD · UNIVERSITY OF FLORIDA · PI DAVID D FULLER · 2003 to 2026
$5.3M
Ampakines and Respiratory NeuroplasticityR01HL139708 · NHLBI · UNIVERSITY OF FLORIDA · PI FULLER, DAVID D · 2018 to 2021
$1.5M
A new method of spinal stimulation TO activate the diaphragmF31HL145831 · NHLBI · UNIVERSITY OF FLORIDA · PI SUNSHINE, MICHAEL · 2019 to 2020
$74k
NHLBI NIH HHS F31 HL145831NHLBI NIH HHS R01 HL139708NICHD NIH HHS T32 HD043730
6 · The paper itself

Abstract

Intraspinal microstimulation (ISMS) can effectively activate spinal motor circuits, but the impact on the endogenous respiratory pattern has not been systematically evaluated. Here we delivered ISMS in spontaneously breathing adult rats while simultaneously recording diaphragm and external intercostal electromyography activity. ISMS pulses were delivered from C2-T1 along two rostrocaudal tracts located 0.5 or 1 mm lateral to midline. A tungsten electrode was incrementally advanced from the dorsal spinal surface and 300μs biphasic pulses (10-90 μA) were delivered at depth increments of 600 μm. Dorsal ISMS often produced fractionated inspiratory bursting or caused early termination of the inspiratory effort. Conversely, ventral stimulation had no discernable impact on respiratory resetting. We conclude that ISMS targeting the ventral spinal cord is unlikely to directly alter the respiratory rhythm. Dorsal ISMS, however, may terminate the inspiratory burst through activation of spinobulbar pathways. We suggest that respiratory patterns should be included as an outcome variable in preclinical studies of ISMS.

Indexed as

AnimalsCervical CordDiaphragmElectric StimulationElectrodes, ImplantedElectromyographyFemaleIntercostal MusclesRatsRats, Long-EvansRespiratory RateSpinal CordCervical spinal cordDiaphragm muscleIntercostal muscleIntraspinal microstimulationResettingRespiration

Identifiers

PMID31734416
PMCPMC7002218

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.