Evidence map›Paper›PMID 31734182›Full record

ArticleGastroenterology2020

Prostaglandin E

Bo Cen, Jessica D Lang, Yuchen Du, Jie Wei, Ying Xiong, Norma Bradley, Dingzhi Wang, Raymond N DuBois

Open access · greenAbstract read
In one paragraph

Article in Gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 65 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Long noncoding RNA (lncRNA)Genes & diseases · 2023
    Review
  15. Review
  16. Article
  17. Metabolism and Colorectal Cancer.Annual review of pathology · 2023
    Review
  18. Review
  19. PGECell communication and signaling : CCS · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Bo CenDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, Charleston, South Carolina.
Jessica D LangBiodesign Institute of Arizona State University, Tempe, Arizona; Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, Arizona.
Yuchen DuBiodesign Institute of Arizona State University, Tempe, Arizona.
Jie WeiDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, Charleston, South Carolina.
Ying XiongDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, Charleston, South Carolina.
Norma BradleyDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, Charleston, South Carolina.
Dingzhi WangDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, Charleston, South Carolina.
Raymond N DuBoisDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, Charleston, South Carolina; Department of Research and Division of Gastroenterology, Mayo Clinic, Scottsdale, Arizona. Electronic address: duboisrn@musc.edu.
Medical University of South Carolina · USArizona State University · USTranslational Genomics Research Institute · US

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
THE ROLE OF ENDOCANNABINOIDS AND THEIR RECEPTORS IN COLORECTAL CANCERP01CA077839 · NCI · VANDERBILT UNIVERSITY · PI YANG, PEIYING · 1999 to 2016
$17.8M
Nuclear Hormone Receptors in Intestinal BiologyR01DK062112 · NIDDK · VANDERBILT UNIVERSITY · PI DUBOIS, RAYMOND N. · 2002 to 2010
$3.0M
Role of Eicosanoids in Intestinal BiologyR01DK047297 · NIDDK · VANDERBILT UNIVERSITY · PI DUBOIS, RAYMOND N. · 1994 to 2018
$2.6M
(PQA1)The Molecular Mechanisms Underlying Effects of Aspirin on Colorectal CancerR01CA184820 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DUBOIS, RAYMOND N. · 2014 to 2017
$1.6M
Characterization of the role of super-enhancers in ovarian cancer treatment responseK99CA234391 · NCI · TRANSLATIONAL GENOMICS RESEARCH INST · PI LANG, JESSICA DIANE · 2019 to 2020
$223k
NCATS NIH HHS UL1 TR001450NCI NIH HHS K99 CA234391NCI NIH HHS P01 CA077839NCI NIH HHS R01 CA184820NIDDK NIH HHS R01 DK047297NIDDK NIH HHS R01 DK062112
6 · The paper itself

Abstract

BACKGROUND &

aimsProstaglandin E

methodsWe incubated LS174T colorectal cancer cells with PGE

resultsWe identified miRNA 675-5p (miR675-5p) as the miRNA most highly up-regulated by incubation of colorectal cancer cells with PGE

conclusionsWe found that treatment of mice with PGE

Indexed as

Colorectal NeoplasmsCyclooxygenase 1Cyclooxygenase 2DinoprostoneHumansMicroRNAsNeoplasm MetastasisRNA, Long NoncodingTumor Cells, CulturedTumor Suppressor Protein p53Up-RegulationCyclooxygenase 1Cyclooxygenase 2DinoprostoneH19 long non-coding RNAMicroRNAsMIRN6754 microRNA, humanRNA, Long NoncodingTP53 protein, humanTumor Suppressor Protein p53Gene RegulationInflammationPosttranscriptional ModificationTumor Suppressor

Identifiers

PMID31734182
PMCPMC7062589
OpenAlexW2985941554

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.